Correlation of Elevated Serum LDH Levels with Adverse Maternal and Perinatal Outcome in Preeclampsia

AIM OF THE STUDY: To study the correlation between the elevated serum lactate dehydrogenase level with the severity of disease and maternal and perinatal outcome in pre-eclampsia. OBJECTIVES: 1. Correlation of the levels of serum lactate dehydogenase with severity and maternal and fetal complications of pre-eclampsia. 2. Role of serum lactate dehydrogenase as a biochemical marker in pre-eclampsia so as to decrease maternal morbidity and mortality. SOURCE OF STUDY: Study group consists of preeclamptic pregnant women who is admitted in Coimbatore Medical College Hospital in the department of Obstetrics and Gynaecology. Design of Study: Prospective study. PERIOD OF STUDY: May 2017-April 2018. Sample Size: 200. Inclusion Criteria: Primi / Multigravida, Antenatal women with pre-eclampsia, more than 20 weeks of gestation, 18- 35 years of age with singleton pregnancy. Exclusion Criteria: Antenatal mothers with hypertension at/ before20 weeks of gestation. Patients with history of liver disease ,hemolytic disease, diabetes mellitus, multiple pregnancy, renal disease, stroke, connective tissue disorders, thyroid disorder, epilepsy, smoking alcohol behaviour and those on hepatotoxic drugs. Preeclampsia which is a multisystem disorder in pregnancy, leading to maternal as well as perinatal morbidity and mortality. In preeclampsia, there is systemwide endothelial dysfunction and vasospasm and the resulting cellular damage due to hypoxia causes multiorgan damage. Serum lactate dehydrogenase which is an intracellular enzyme which converts pyruvic acid into lactate in anerobic conditions. serum LDH level can be used as a marker to assess the severity of disease and also to predict the occurrence of complications of preeclampsia like eclampsia, HELLP syndrome, acute renal failure, acute pulmonary edema, abruptio placenta, and cortical vein thrombosis. In this study, 200 antenatal women with preeclampsia were included and serum LDH was done. Based on the serum LDH levels, patients were divided into three groups and followed until ...