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Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP103108

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  • معلومة اضافية
    • Contributors:
      Department of Chemical Sciences, Complesso Universitario Monte Sant'Angelo; University of Naples Federico II = Università degli studi di Napoli Federico II; Department of Biotechnology and Biosciences; Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB); Laboratoire des symbioses tropicales et méditerranéennes (UMR LSTM); Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro); Leibniz Lung Center, Junior Group of Allergobiochemistry; Research Center Borstel - Leibniz Lung Center Germany; European Commission H2020-MSCA-ETN-642157; European Project: 642157,H2020,H2020-MSCA-ITN-2014,TOLLerant(2015)
    • بيانات النشر:
      HAL CCSD
      Elsevier
    • الموضوع:
      2018
    • Collection:
      CIRAD: HAL (Recherche agronomique pour le développement / Agricultural Research for Development)
    • نبذة مختصرة :
      Acetobacter pasteurianus is an acetic add-producing Gram-negative bacterium commonly found associated with plants and plant products and widely used in the production of fermented foods, such as kefir and vinegar. Due to the acid conditions of the bacterium living habitat, uncommon structural features composing its cell envelope are expected. In the present work we have investigated the A. pasteurianus CIP103108 lipopolysaccharide (LPS) structure and immunoactivity. The structure of the lipid A and of two different O-polysaccharides was assessed. Furthermore, immunological studies with human cells showed a low immunostimulant activity of the isolated LPS, in addition to a slight capability to lower the NF-kappa B activation upon stimulation by toxic LPS.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/30098357; info:eu-repo/grantAgreement//642157/EU/Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach./TOLLerant; hal-01956104; https://hal.science/hal-01956104; https://hal.science/hal-01956104/document; https://hal.science/hal-01956104/file/2018_Pallach_International%20Journal%20of%20Biological%20Macromolecules.pdf; PRODINRA: 455867; PUBMED: 30098357; WOS: 000447682100114
    • الرقم المعرف:
      10.1016/j.ijbiomac.2018.08.035
    • Rights:
      http://creativecommons.org/licenses/by-nc-nd/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.6868CDE7