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Oral HPV16 prevalence in oral potentially malignant disorders and oral cavity cancers

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  • معلومة اضافية
    • بيانات النشر:
      MDPI AG
    • الموضوع:
      2020
    • Collection:
      Queensland University of Technology: QUT ePrints
    • نبذة مختصرة :
      The role of human papillomavirus type 16 (HPV16) in oral potentially malignant disorders (OPMD) and oral cavity carcinoma (OC) is still under debate. We investigated HPV16 prevalence in unstimulated saliva, oral rinse samples, oral swabs and tumour biopsies collected from OPMD (n = 83) and OC (n = 106) patients. HPV16 genotype, viral load, physical status (episomal vs. integrated) and tumour p16INK4a expression were determined. Oral HPV16 prevalence was higher in OC than in OPMD, but this difference was not statistically significant (7.5% (8/106) versus 3.6% (3/83), odds ratio (OR): 2.18, 95% confidence interval (CI): 0.56, 8.48, p = 0.26). There was a significant association (p < 0.05) between oral HPV16 infection and heavy tobacco consumption. Real-time PCR results indicated that no integration events occurred in either OPMD or OC cases based on the HPV16 E2/E6 ratio. HPV16 positive OPMD and OC patients had similar HPV16 E2 and E6 viral loads. The inter-rater agreement between tumour p16INK4a expression and oral HPV16 infection was considered as fair (k = 0.361) for OC. Our data suggest that the involvement of HPV16 in oral carcinogenesis is limited.
    • File Description:
      application/pdf
    • Relation:
      https://eprints.qut.edu.au/198358/1/Oral_HPV16_Prevalence_in_Oral_Potentially_Malignant_Disorders_and_Oral_Cavity_Cancers.pdf; Tang, Kai Dun, Menezes, Lilian, Baeten, Kurt, Walsh, Laurence J., Whitfield, Bernard C.S., Batstone, Martin D., Kenny, Liz, Frazer, Ian H., Scheper, Gert C., & Punyadeera, Chamindie (2020) Oral HPV16 prevalence in oral potentially malignant disorders and oral cavity cancers. Biomolecules, 10(2), Article number: 223.; https://eprints.qut.edu.au/198358/; Centre for Biomedical Technologies; Institute of Health and Biomedical Innovation; Faculty of Engineering
    • Rights:
      free_to_read ; http://creativecommons.org/licenses/by/4.0/ ; 2020 by the authors ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
    • الرقم المعرف:
      edsbas.678099D4