Therapeutic education and physical activity are feasible and safe in hematologic cancer patients referred to chemotherapy: results of a randomized controlled trial

Purpose: Although over 60% of patients with hematologic cancer report distressing fatigue,theyoftendo not receive recommendations on fatigue management strategies. The aim of this pilot study was to estimate the feasibility oftherapeutic education and physical activity (TEPA)by measuring the patients’ adherence to this multidimensional intervention.The secondary aim was toestimatethe impact of TEPA on clinical outcomes. Methods: Patients with hematologic cancer participated in thissingle-center, open-label,randomized controlled trial. The control group (CG) received two educational group sessions on fatigue and physical activity. The experimental group (EG) received the two educational sessions plus six weekly individual sessions aimed at implementing a personalized physical exerciseprogram.Follow-ups were at 1, 3,and 7months. Results: Forty-sixpatients referred to chemotherapy were included, corresponding to 54% of recruitment rate. Adherencereached 90% in the EG and 68% in the CG. Most patients (65% in EG and 64% in CG) attended a minimum of 80% of the planned sessions. Overall retention rate was 87% (85% in EG and 91% in CG). No adverse events were registered. No between-groupdifferences were detected in fatigue (FACIT-F), psychological distress (NCCN Distress Thermometer), QoL (EORTC QLQ-C30), or functional exercisecapacity (TUG test and 6MWT). Adherence to an active lifestyle, measured by a semi-structured interview, increased from 56.5 to 84% inthe EG at 7months (p = 0.02), whereas it decreased slightly in the CG (from 47.8 to 42.9%). Conclusion: Multidimensional rehabilitation interventions are feasible and safe in this population, and larger trials should focus on the efficacy of such approaches on clinically relevant outcomes. Trial registration: ClinicalTrials.gov Identifier: NCT03403075.