Os efeitos do treinamento físico, associado ao perindopril, na rigidez arterial de ratos espontaneamente hipertensos ; Effects of physical training, associated with perindopril, on arterial stiffness of spontaneously hypertensive rats

Hypertension (HT) is a complex and multifactorial disease considered one of the main risk factor for cardiovascular diseases. It is maintained mainly by structural changes in vessels that contribute to increase vascular resistance. Changes in the intrinsic elastic properties of the vessel wall contribute to determine arterial stiffness and may compromise vessel functioning. Currently, arterial stiffness has been considered an important predictor of cardiovascular mortality. Among the antihypertensive treatments, angiotensin converting enzyme inhibitors (ACEi) have been used to improve vessel compliance, however, almost nothing is known about the use of ACEi, associated or not with aerobic TF, on the improvement of arterial stiffness in hypertensive animals. We hypothesized that T associated with perindopril could improve arterial stiffness and HT higher than isolated treatments. Therefore, the aim of this study was to investigate the effects of aerobic T, associated or not with perindopril treatment on arterial stiffness, arterial pressure and cardiac remodeling in spontaneously hypertensive rats (SHR). 49 SHR (200-300g) were randomly allocated into 4 groups: 1 / sedentary control (SC, n = 12) 2 / sedentary treated with perindopril (SP, n = 10, 3 mg / kg per day, by gavage) 3 / trained control (TC, n = 13, which underwent treadmill aerobic exercise per 60 days), 4 / trained perindopril (TP, n = 14, which underwent aerobic TF and were treated with perindopril). Ten wistar rats were used as normotensive control. Weekly tail pressure measurements were measured. At the end of experimental protocol, pulse wave velocity (PWV) was performed to analyze arterial stiffness. After measurement of direct arterial pressure (AP), autonomic balance and barroreflex analysis, aorta artery was removed for proteomic analysis and muscle tissues (soleus and left ventricle) for histological analyses. The sedentary hypertensive rats (SC) presented lower body weight (-26.51%) and lower SOL weight (-26%) compared to wistar rats. However, ...