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Insular interictal positron emission tomography hypometabolism in patients with ictal asystole

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Institut de Neurosciences des Systèmes (INS); Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service de neurophysiologie clinique Hôpital de la Timone - APHM; Hôpital de la Timone CHU - APHM (TIMONE); King's College Hospital (KCH); King‘s College London; Institut FRESNEL (FRESNEL); Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS); Centre Européen de Recherche en Imagerie médicale (CERIMED); Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes (IPC); Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS); Imagerie MOléculaire pour applications THéranostiques personnalisées (IMOTHEP); Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Hôpital de la Timone CHU - APHM (TIMONE); ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011)
    • بيانات النشر:
      HAL CCSD
      Wiley
    • الموضوع:
      2021
    • Collection:
      Aix-Marseille Université: HAL
    • نبذة مختصرة :
      International audience ; We aimed to explore brain area(s) involved in the generation of ictal asystole (IA) by analyzing the interictal positron emission tomography (PET) metabolism of patients with IA recorded by video-electroencephalography or video-stereo-electroencephalography. We identified in our cohort of focal epilepsy patients who had undergone presurgical evaluation those who had a recorded period of IA of more than 3 s. We investigated the anatomometabolic changes (interictal 18 F-fluorodeoxyglucose PET) of these patients in comparison with (1) healthy subjects with similar age and sex distribution (n = 19) using whole-brain voxel-based analysis (p-voxel < .001, p-cluster < .05, uncorrected) and (2) patients without IA with similar age and seizure onset zone (n = 55). We found 12 patients with IA. Epilepsy was mainly temporal (four right temporal mesial, four bitemporal, two left temporal lateral, one right temporal lateral, and one right temporal "plus"). Seven patients had negative magnetic resonance imaging. Whole-brain statistical analysis of PET imaging was performed at the voxel level, showing that in comparison to healthy subjects and to epileptic patients without IA, a hypometabolism in the right posterior insula characterized epileptic patients with IA. Our study suggests involvement of the right posterior insula-a part of the central autonomic network-in the pathophysiological mechanism of IA.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/34227678; hal-03563019; https://hal.science/hal-03563019; https://hal.science/hal-03563019/document; https://hal.science/hal-03563019/file/PET%20ictal%20asystole_Epilepsia_Manuscript_R2.pdf; PUBMED: 34227678
    • الرقم المعرف:
      10.1111/epi.16981
    • الدخول الالكتروني :
      https://hal.science/hal-03563019
      https://hal.science/hal-03563019/document
      https://hal.science/hal-03563019/file/PET%20ictal%20asystole_Epilepsia_Manuscript_R2.pdf
      https://doi.org/10.1111/epi.16981
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.65EA54E2