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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Complex Disease Genetics; Research Programs Unit; CAMM - Research Program for Clinical and Molecular Metabolism; Faculty of Medicine; University of Helsinki; HUS Children and Adolescents; Lastentautien yksikkö; Clinicum; Children's Hospital; Helsinki University Hospital Area; HUS Internal Medicine and Rehabilitation; Department of Medicine; Department of Biochemistry and Developmental Biology; Centre of Excellence in Complex Disease Genetics; HUS Abdominal Center; Institute for Molecular Medicine Finland; Endokrinologian yksikkö; Department of Public Health
    • بيانات النشر:
      Nature Publishing Group
    • الموضوع:
      2021
    • Collection:
      Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto
    • نبذة مختصرة :
      Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ; Peer reviewed
    • File Description:
      application/pdf
    • Relation:
      P. Surendran is supported by a Rutherford Fund Fellowship from the Medical Research Council (grant no. MR/S003746/1). N.L. is supported by the Foundation "De Drie Lichten' in the Netherlands and the Netherlands Cardiovascular Research Initiative, an initiative supported by the Dutch Heart Foundation (CVON2012-10 PREDICT and CVON2018-30 PREDICT2). S. Karthikeyan and B.P. are funded by a BHF Programme Grant (RG/18/13/33946). J.N.H. was supported by the Vanderbilt Molecular and Genetic Epidemiology of Cancer (MAGEC) Training Program (T32CA160056, PI X.-O.S.). N.F. is supported by the National Institute of Health awards HL140385, MD012765 and DK117445. E.Y.-D. was funded by the Isaac Newton Trust/Wellcome Trust ISSF/University of Cambridge Joint Research Grants Scheme. R.C. is funded by a Medical Research Council-Newton Project Grant to study genetic risk factors of cardiovascular disease among Southeast Asians and a UK Research and Innovation-Global Challenges Research Fund Project Grant (CAPABLE) to study risk factors of non-communicable diseases in Bangladesh. F.W.A. is supported by UCL Hospitals NIHR Biomedical Research Centre. P.D. was supported by the British Heart Foundation (BHF) grant RG/14/5/30893. R.J.F.L. is funded by grants R01DK110113, U01HG007417, R01DK101855 and R01DK107786. C.H. is supported by MRC University Unit Programme grants MC_UU_00007/10 (QTL in Health and Disease) and MC_PC_U127592696. M.I.M* was a Wellcome Senior Investigator (098381; 212259) and an NIHR Senior Investigator (NF-SI-0617-10090). The research was supported by the NIHR Oxford Biomedical Research Centre (BRC) and by the Wellcome Trust (090532, 106130, 098381, 203141 and 212259). The views expressed by C.Y., S.H., J.R. and G.J.P. are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the US Department of Health and Human Services. T.F.* is supported by the NIHR Biomedical Research Centre in Oxford. M.J. is supported by PrevMetSyn/SALVE, H2020 DynaHEALTH action (grant agreement 633595), EU H2020-HCO-2004 iHEALTH Action (grant agreement 643774). K.-H.H. is supported by PrevMetSyn/SALVE, H2020 DynaHEALTH action (grant agreement 633595) and EU H2020-HCO-2004 iHEALTH Action (grant agreement 643774). N.S. is supported by the British Heart Foundation Research Excellence Award (RE/18/6/34217). J.P. is supported by a UKRI Innovation Fellowship at Health Data Research UK. N.F. is supported by NIH awards R01-DK117445, R01-MD012765 and R21-HL140385. G.D.S., T.R.G. and C.L.R. work in the Medical Research Council Integrative Epidemiology Unit at the University of Bristol, which is supported by the Medical Research Council (MC_UU_00011/1, 4 & 5). S.T. holds a Junior 1 Clinical Research Scholar award from the Fonds de Recherche du Quebec-Sante (FRQS). M.T. is supported by the BHF (PG/17/35/33001 and PG/19/16/34270) and Kidney Research UK (RP_017_20180302). V.S.R. is supported in part by the Evans Medical Foundation and the Jay and Louis Coffman Endowment from the Department of Medicine, Boston University School of Medicine. J.D.* holds a British Heart Foundation Professorship and a National Institute for Health Research Senior Investigator Award. C.M.L.* is supported by the Li Ka Shing Foundation, WT-SSI/John Fell funds and by the NIHR Biomedical Research Centre, by Widenlife and the National Institutes of Health (5P50HD028138-27). J.M.M.H.* was funded by the NIHR (Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust).; Surendran , P , Feofanova , E , Lahrouchi , N , Ntalla , I , Karthikeyan , S , Cook , J , Chen , L , Mifsud , B , Yao , C , Kraja , A T , Cartwright , J H , Hellwege , J N , Giri , A , Tragante , V , Thorleifsson , G , Liu , D J , Prins , B P , Stewart , I D , Cabrera , C P , Eales , J M , Akbarov , A , Auer , P L , Bielak , L F , Bis , J C , Braithwaite , V S , Brody , J A , Daw , E W , Warren , H R , Drenos , F , Nielsen , S F , Faul , J D , Fauman , E B , Fava , C , Ferreira , T , Foley , C N , Franceschini , N , Gao , H , Giannakopoulou , O , Giulianini , F , Gudbjartsson , D F , Guo , X , Harris , S E , Havulinna , A S , Helgadottir , A , Huffman , J E , Hwang , S-J , Kanoni , S , Kontto , J , Larson , M G , Li-Gao , R , Lindström , J , Lotta , L A , Lu , Y , Luan , J , Mahajan , A , Malerba , G , Masca , N G D , Mei , H , Menni , C , Mook-Kanamori , D O , Mosen-Ansorena , D , Muller-Nurasyid , M , Pare , G , Paul , D S , Perola , M , Poveda , A , Rauramaa , R , Richard , M , Richardson , T G , Sepulveda , N , Sim , X , Smith , A , Smith , J A , Staley , J R , Stanakova , A , Sulem , P , Theriault , S , Thorsteinsdottir , U , Trompet , S , Varga , T V , Edwards , D R V , Veronesi , G , Weiss , S , Willems , S M , Yao , J , Young , R , Yu , B , Zhang , W , Zhao , J-H , Zhao , W , Zhao , W , Evangelou , E , Aeschbacher , S , Asllanaj , E , Blankenberg , S , Bonnycastle , L L , Bork-Jensen , J , Brandslund , I , Braund , P S , Burgess , S , Cho , K , Christensen , C , Connell , J , de Mutsert , R , Dominiczak , A F , Dorr , M , Eiriksdottir , G , Farmaki , A-E , Gaziano , J M , Grarup , N , Grove , M L , Hallmans , G , Hansen , T , Have , C T , Heiss , G , Jorgensen , M E , Jousilahti , P , Kajantie , E , Kamat , M , Karajamaki , A , Karpe , F , Koistinen , H A , Kovesdy , C P , Kuulasmaa , K , Laatikainen , T , Lannfelt , L , Lee , I-T , Lee , W-J , Linneberg , A , Martin , L W , Moitry , M , Nadkarni , G , Neville , M J , Palmer , C N A , Papanicolaou , G J , Pedersen , O , Peters , J , Poulter , N , Rasheed , A , Rasmussen , K L , Rayner , N W , Magi , R , Renstrom , F , Rettig , R , Rossouw , J , Schreiner , P J , Sever , P S , Sigurdsson , E L , Skaaby , T , Sun , Y , Sundstrom , J , Thorgeirsson , G , Esko , T , Trabetti , E , Tsao , P S , Tuomi , T , Turner , S T , Tzoulaki , I , Vaartjes , I , Vergnaud , A-C , Willer , C J , Wilson , P W F , Witte , D R , Yonova-Doing , E , Zhang , H , Aliya , N , Almgren , P , Amouyel , P , Asselbergs , F W , Barnes , M R , Blakemore , A , Boehnke , M , Bots , M L , Bottinger , E P , Buring , J E , Chambers , J C , Chen , Y-D I , Chowdhury , R , Conen , D , Correa , A , Smith , G D , de Boer , R A , Deary , I J , Dedoussis , G , Deloukas , P , Di Angelantonio , E , Elliott , P , Felix , S B , Ferrieres , J , Ford , I , Fornage , M , Franks , P W , Franks , S , Frossard , P , Gambaro , G , Gaunt , T R , Groop , L , Gudnason , V , Harris , T B , Hayward , C , Hennig , B J , Herzig , K-H , Ingelsson , E , Tuomilehto , J , Jarvelin , M-R , Jukema , J W , Kardia , S L R , Kee , F , Kooner , J S , Kooperberg , C , Launer , L J , Lind , L , Loos , R J F , Majumder , A A S , Laakso , M , McCarthy , M , Melander , O , Mohlke , K L , Murray , A D , Nordestgaard , B G , Orho-Melander , M , Packard , C J , Padmanabhan , S , Palmas , W , Polasek , O , Porteous , D J , Prentice , A M , Province , M A , Relton , C L , Rice , K , Ridker , P M , Rolandsson , O , Rosendaal , F R , Rotter , J , Rudan , I , Salomaa , V , Samani , N J , Sattar , N , Sheu , W H-H , Smith , B H , Soranzo , N , Spector , T D , Starr , J M , Sebert , S , Taylor , K D , Lakka , T A , Timpson , N J , Tobin , M D , van der Harst , P , van der Meer , P , Ramachandran , V S , Verweij , N , Virtamo , J , Volker , U , Weir , D R , Zeggini , E , Charchar , F J , Wareham , N J , Langenberg , C , Tomaszewski , M , Butterworth , A S , Caulfield , M J , Danesh , J , Edwards , T L , Holm , H , Hung , A M , Lindgren , C M , Liu , C , Manning , A K , Morris , A P , Morrison , A C , O'Donnell , C J , Psaty , B M , Saleheen , D , Stefansson , K , Boerwinkle , E , Chasman , D , Levy , D , Newton-Cheh , C , Munroe , P B & Howson , J M M 2020 , ' Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals ' , Nature Genetics , vol. 52 , no. 12 , pp. 1314-1332 . https://doi.org/10.1038/s41588-020-00713-x; ORCID: /0000-0002-8306-6202/work/86486030; ORCID: /0000-0001-7870-070X/work/104829459; http://hdl.handle.net/10138/330184; 98caf9fc-7087-444b-a631-0af02df4b21a; 000592028900001
    • الدخول الالكتروني :
      http://hdl.handle.net/10138/330184
    • Rights:
      info:eu-repo/semantics/openAccess ; openAccess
    • الرقم المعرف:
      edsbas.65AA81F5