Contributors: Ontario Institute for Cancer Research Canada (OICR); Ontario Institute for Cancer Research; Department of Clinical Neurosciences Cambridge; University of Cambridge UK (CAM); McGill University = Université McGill Montréal, Canada; Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN); Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU); Dalla Lana School of Public Health; University of Toronto; Department of medecine; University of Ottawa Ottawa; Nutrition, obésité et risque thrombotique (NORT); Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); CHU Trousseau APHP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Samuel Lunenfeld Research Institute; Mount Sinai Hospital Toronto, Canada (MSH); Division of general surgery; Toronto General Hospital Research Institute Canada (TGHRI); University Health Network Toronto, ON, Canada -University Health Network Toronto, ON, Canada; Department of Molecular Genetics Toronto; Department of Medical Biophysics (MBP); Ontario Research Fund (GL2 competition); Canadian Institutes of Health Research; Ontario Institute for Cancer Research from the Ontario Ministry of Research and Innovation; National Cancer Institute, National Institutes of Health CA-95-011; Cambridge NIHR Biomedical Research Centre; UK Medical Research Council G1100125; CIHR; FRSQ (RMGA); Program Hospitalier de Recherche Clinique; GenMed LABEX ANR-10-LABX-0013; Canadian Institutes of Health Research MOP 86466; MOP86466; Heart and Stroke Foundation of Canada T6484; Region Ile de France; Pierre and Marie Curie University; ICAN Institute for Cardiometabolism and Nutrition; ANR-10-IAHU-05; Region Ile de France (CORDDIM); ANR-10-LABX-0013,GENMED,Medical Genomics(2010); European Project: 201413,EC:FP7:HEALTH,FP7-HEALTH-2007-A,ENGAGE(2008)
نبذة مختصرة : International audience ; The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (meQTL). Here we report that in a panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated with at least one distal (trans) single-nucleotide polymorphism (SNP) (Po3.2 Â 10 À 13 ; FDRo5%). These trans-meQTLs include 1,657 SNP–CpG pairs from different chromosomes and 262 pairs from the same chromosome that are 41 Mb apart. Over 90% of these pairs are replicated (FDRo5%) in at least one of two independent data sets. Genomic loci harbouring trans-meQTLs are significantly enriched (Po0.001) for long non-coding transcripts (2.2-fold), known epigenetic regulators (2.3-fold), piwi-interacting RNA clusters (3.6-fold) and curated transcription factors (4.1-fold), including zinc-finger proteins (8.75-fold). Long-range epigenetic networks uncovered by this approach may be relevant to normal and disease states.
Processing Request
No Comments.