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Major Urinary Proteins on Nanodiamond-Based Resonators Toward Artificial Olfaction

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  • معلومة اضافية
    • Contributors:
      Laboratoire Capteurs Diamant (CEA, LIST) (LCD (CEA, LIST)); Département Métrologie Instrumentation & Information (CEA, LIST) (DM2I (CEA, LIST)); Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)); Direction de Recherche Technologique (CEA) (DRT (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay; Università degli Studi di Padova = University of Padua (Unipd); School of Chemical Engineering and Analytical Sciences Manchester; University of Manchester Manchester; European Project: 285203,EC:FP7:SEC,FP7-SEC-2011-1,SNIFFER(2012)
    • بيانات النشر:
      HAL CCSD
      Institute of Electrical and Electronics Engineers
    • الموضوع:
      2016
    • Collection:
      HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives)
    • نبذة مختصرة :
      International audience ; A new bio-sensing platform based on major urinary proteins (MUPs) from the mouse as chemical recognition elements has been developed. The transducers were surface acoustic devices coated with diamond nanoparticles as an intermediate layer enabling covalent attachment of the proteins. The resulting sensors detected 2,4-Dinitrotoluene, 4-Nitrotoluene, and 2-Isobutyl-3-methoxypyrazine at ppb levels. The best sensor showed a sensitivity of 24 000 Hz . ppm(-1) to 2, 4-DNT when grafted with the protein MUP20. Trends in the sensitivity of the various VOC sensors were compared with the association constant values K-a of the proteins to target ligands measured by competitive assay in liquid phase. The system is able to detect analytes both in liquid as well as vapor phase and indicate that MUPs are robust bio-recognition elements that can be utilized in artificial olfaction applications.
    • Relation:
      info:eu-repo/grantAgreement/EC/FP7/285203/EU/A bio-mimicry enabled artificial sniffer/SNIFFER; hal-01869478; https://hal.science/hal-01869478; https://hal.science/hal-01869478/document; https://hal.science/hal-01869478/file/article_EmmanuelScorsone_IEEE2016.pdf
    • الرقم المعرف:
      10.1109/JSEN.2016.2585187
    • الدخول الالكتروني :
      https://hal.science/hal-01869478
      https://hal.science/hal-01869478/document
      https://hal.science/hal-01869478/file/article_EmmanuelScorsone_IEEE2016.pdf
      https://doi.org/10.1109/JSEN.2016.2585187
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.657AA10F