Executive function disorders and anxiety-depressive symptoms in children and adolescents with mitochondrial diseases ; Troubles des fonctions exécutives et symptomatologie anxio-dépressive chez les enfants et adolescents atteints de pathologies mitochondriales

Advances in neuroscience make it possible to link psychiatric illnesses,neuropsychological symptoms and cerebra ldysfunctions. Since brain function requires alarge amount of energy, mitochondria,organelles essential in cellular energy processes, are described as a line of researchof great interest in neurology and psychiatry. Agrowing body of work describes potential links between mitochondrial dysfunction and psychiatric symptomatology. Well described neurologically and somatically, the symptomatology of these disorders is muchless in its psychiatric aspects. However,psychiatric symptoms are frequently associated and this semiology has already been described in adult patients.The hypothesis of an impairment of executivecontrol functions in children with mitochondrialdisease is justified, given the signs of dysfunction identified in certain areas of thebrain and the presence of intracerebral metabolites (lactates, etc.) likely to disrupt the development of the frontal-subcortical networks in these children. It would therefore be aquestion of understanding the mechanisms at the origin of clinical symptoms in mitochondrial pathologies in children and adolescence by focusing the analysis on the psychiatric profile and more specifically anxiety and depression,the neuropsychological profile and more precisely the study of executive functions. ; Les avancées des neurosciences permettent de mettre en lien maladies psychiatriques, symptômes neuropsychologiques et dysfonctionnements cérébraux. Le fonctionnement cérébral requérant une grande quantité d’énergie, les mitochondries, organites essentiels dans les processus énergétiques cellulaires, sont considérées comme une voie de recherche de grand intérêt en neurologie et en psychiatrie. Un nombre croissant de travaux décrivent des liens potentiels entre dysfonctionnement mitochondrial et symptomatologie psychiatrique.Bien décrite sur le plan neurologique et somatique, la symptomatologie de ces troubles l’est nettement moins dans ses aspects psychiatriques. Pourtant, des ...