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Vaistų monitoringo svarba klinikinėje praktikoje - aminoglikozidinių antibiotikų koncentracijų kraujyje įvertinimas ; Importance of drugs monitoring in clinical practice - evaluation of aminoglycosides antibiotc concentration in blood

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  • معلومة اضافية
    • Contributors:
      Kaduševičius, Edmundas; Saint-Marcoux, Franck
    • بيانات النشر:
      Institutional Repository of Lithuanian University of Health Sciences
    • الموضوع:
      2008
    • Collection:
      LSRC VL (Lithuanian Social Research Centre Virtual Library) / LSTC VB (Lietuvos socialinių tyrimų centras virtualią biblioteką)
    • نبذة مختصرة :
      Objectives: To evaluate the importance of researh on aminoglicozids for rational pharmacotherapy. To determine and evaluate the tendencies of studies of amikacin and gentamicin concentration in Limoges University Hospital (CHU) and Kaunas University of medicine Hospital (KMUM). Methods: The data has been received from the department of pharmacology and toxicology and the department of statistics of CHU and from the laboratory of chemistry and hematology and the department of statistics of KMUK. It has been calculated how much concentration study belongs to one bed-day in the year 2007, the data of the studied concentrations of gentamicin and amikacin have been evaluated and the doses have been administered. Statistical analysis of the data has been carried out by the use of MS Excel and data processing programs of MS Office. Results: 400 concentration studies have been carried out for gentamicin (184 cases for the study of Cmax concentration, 216 cases for the study of Cmin concentration). 131 patients (46 women and 85 men), who have been individually adapted the dose of gentamicin for 221 time, have been studied. 169 concentration studies have been carried out for amikacin (82 cases for the study of Cmax concentration, 87 cases for the study of Cmin concentration). 62 patients (24 women and 38 men), who have been individually adapted the dose of amikacin for 92 times. In CHU, there is 6.85×10-4 (1:1460) of gentamicin concentration study for one bed-day and 2.89×10-4 (1:3456) of amikacin concentration study for one bed-day. In KUH, there is 2.77×10-5 (1:36089) of gentamicin concentration study for one bed-day. Thus, CHU sometimes overtakes KUH by 24.72 times in gentamicin concentration studies. The concentrations of gentamicin Cmax in the blood are the following: suitable - 38%, too high - 5%, too low - 57%. When individualizing the doses, the concentrations of gentamicin Cmax after the third adaptation are the following: suitable 71%, too high 14%, too low 15%. Concentrations of amikacin Cmax in the blood are ...
    • File Description:
      application/pdf
    • Relation:
      http://lsmu.oai.elaba.lt/documents/1893531.pdf; http://lsmu.lvb.lt/LSMU:ELABAETD1893531&prefLang=en_US
    • الدخول الالكتروني :
      http://lsmu.oai.elaba.lt/documents/1893531.pdf
      http://lsmu.lvb.lt/LSMU:ELABAETD1893531&prefLang=en_US
    • Rights:
      info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.632A9F65