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Risk factors and prevention of nosocomial pneumonia in polytrauma ; Факторы риска и профилактика нозокомиальной пневмонии при политравме

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Pulmonology
    • الموضوع:
      2020
    • Collection:
      Pulmonology (E-Journal) / Пульмонология
    • نبذة مختصرة :
      Nosocomial pneumonia (NK) is one of the most frequent complications of polytrauma leading to death. Meanwhile, the recommendations on prevention of NK in case of polytrauma have not been specified so far. This is due in large part to the lack of study of the pathophysiology of severe combined trauma. The review presents the results of modern experimental and clinical studies of the effect of shock, immune distress syndrome, posttraumatic immunosuppression, the phenomenon of mutual aggravation of lesions, age, sex, concomitant pathology on the risk of NK in polytrauma. The role of iatrogenic risk factors for NK in polytrauma – intubation of trachea and artificial lung ventilation (AVL), massive hemotransfusions, immobilization, the phenomenon of “second strike” after multiple surgeries has been determined. The most effective measures of NK prevention are reduction of the duration of AVL, prevention of oropharyngeal colonization and aspiration in case of AVL, use of inhalation antibacterial drugs, antishock measures, early mobilization of the patient, the earliest possible stable functional osteosynthesis by minimally traumatic methods. The data on the effectiveness of selective decontamination of intestines, probiotics and glucocorticosteroids for the prevention of NK in polytrauma are inconsistent. A promising area of NK prophylaxis may be the development of agents that regulate the complex mechanisms of immune response to polytrauma and prevent secondary acute lung injury and post-traumatic immunosuppression. ; Нозокомиальная пневмония (НКП) относится к наиболее частым осложнениям политравмы (ПТ), приводящим к смерти. Между тем рекомендации по профилактике НКП при ПТ к настоящему времени не конкретизированы. Во многом это связано с недостаточной изученностью патофизиологии тяжелой сочетанной травмы. В обзоре представлены результаты современных экспериментальных и клинических исследований влияния шока, иммунного дистресс-синдрома, посттравматической иммуносупрессии, феномена взаимного отягощения повреждений, ...
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      application/pdf
    • Relation:
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    • الرقم المعرف:
      10.18093/0869-0189-2020-30-4-493-503
    • الدخول الالكتروني :
      https://journal.pulmonology.ru/pulm/article/view/2156
      https://doi.org/10.18093/0869-0189-2020-30-4-493-503
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      Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). ; Авторы, публикующие статьи в данном журнале, соглашаются на следующее:Авторы сохраняют за собой авторские права и предоставляют журналу право первой публикации работы, которая по истечении 6 месяцев после публикации автоматически лицензируется на условиях Creative Commons Attribution License , которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале.Условия передачи авторских прав: Автору (уполномоченному лицу) статьи следует скопировать форму Авторского договора, заполнить ее, отсканировать и прислать в редакцию.
    • الرقم المعرف:
      edsbas.61C6A325