Traitement personnalisé dans l'asthme : le cas des anticorps monoclonaux dirigés contre l'interleukine-5. ; Personalized treatment of asthma : the issue of anti-interleukine-5 antibodies

peer reviewed ; Asthma is a chronic inflammatory disease that often features eosinophilia, especially in its most severe forms. Monoclonal antibodies directed towards interleukin-5, such as mepolizumab or reslizumab, were shown to be very effective at reducing blood and airways eosinophilia. When administered monthly by intravenous or subcutaneous injection in severe eosinophilic asthmatic patients, they reduce severe exacerbation rate by 50 %, improve asthma control and quality of life, and have an oral glucocorticoids sparing effect in those requiring oral corticoids as maintenance therapy.