CD166 as Cancer Stem Cells Marker Based on Colorectal Cancer Location and Individual Characteristic

Colorectal cancer stem cells (CR-CSCS) are associated with a sub-population of colorectal cancer (CRC)with stem-cell properties that have s crucial role eith in chemotherapy resitance or in recurrency of CRC. CR0CSCs express high levels of CD166 in the colorectal; however, their expression, based on thespecific location of CRC and individual characteristics, remains unclear. The objecive of this study was to investigate the CD166 exppressionbased on the locationof the proximal colon, distal colon and rectum, and individual profile. This was a cross-sectional study performed at the Internal Medicine Department, Faculty of Medicine, Adam Malik General Hospital and affiliation hospital from September, 2018 to July, 2019. The CRC tissue was taken from colonoscopy biopsy and surgical resection of CRC patients that fulfilled inclusion and exclusion criteria and signed informed consent. We examined immunohistochemistry for analyzing the CD166 expression.Of the 118 subjects, 69 (58.5%) them were males, and the expression of CD166 high and low level were 45 (38.1%) and 43 (36.4%), respectively. There were no significant differences in age, sex, and BMI between high and low-level CD166 expression. There was no significant difference in laboratory findings between high and low-level CD166 expression. Based on tumor location, CD166 expression was significantly higher at distal colon than at the rectum (p=0.047). CD166 expression was associated with tumor location, and not with gender, sex, and laboratory parameters. Keywords: Colorectal cancer stem cell, CD 166, tumor location.