Pseudopulchellol: A unique sesquiterpene-monoterpene derived C-25 terpenoid from the leaves of Croton pseudopulchellus Pax (Euphorbiaceae)

International audience ; A C-25 terpenoid, pseudopulchellol, a rare example of a compound formed by the combination of a monoterpenoid and a sesquiterpenoid unit, was isolated along with eudesm-4(15)-en-1β,6α-diol, its likely precursor, and nine known compounds, including six ent-kaurenoic acids, from the leaves of Croton pseudopulchellus. The Logic for Structure Determination (LSD) protocol was used to determine that pseudopelchellol consisted of the sesquiterpene, eudesm-4(15)-ene-6α-ol, attached at the C-1β position to C10 of the monoterpene, α-pinene. The Electronic circular dichroism (ECD) studies were used to assign the absolute configuration of pseudopulchellol.