Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease

We are medical librarians conducting an experiment to understand the global visibility of non-English medical research articles. The translation for this abstract was performed by a certified translator. The PubMed citation and link to the whole open access article can be found here https://www.ncbi.nlm.nih.gov/pubmed/?term=23666091 . Please feel free to add your comments below on the project and, if you are a native-speaker, on the quality of the translation.--Lilian Hoffecker and Dana Abbey, Health Sciences Library, University of Colorado. ; Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease Abstract Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.