Analysis of Adverse Reactions of Cosmetics in Chinese Han Population in Recent Five Years

Canbin Dong,1,* Fang Liu,1,* Zuda Liao,2 Lanmei Lin,1 Runnan Wang,1 Juan Du,1 Wen Huang1 1Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai, People’s Republic of China; 2Medical Insurance Office of Huashan Hospital Affiliated, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Juan Du; Wen Huang, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai, 200040, People’s Republic of China, Tel +86-21-52889999, Fax +86-21-52887782, Email dujuan@huashan.org.cn; huangwen2@huashan.org.cnBackground: There are still some gaps in the summary and generalization of cosmetic-related adverse reaction reports.Objective: The aim of this study is to summarize and analyze the occurrence of cosmetic adverse reactions in Shanghai Han population by using available survey data.Materials and Methods: Collection, statistics and analysis of patients with cosmetic adverse reactions in Shanghai Huashan Hospital from 2017 to 2021.Results: Among the 1004 patients, most of them (96.71%) were diagnosed as cosmetic contact dermatitis, which often occurred within 3 days of using cosmetics (51.79%). A total of 260 patients were tested with patch test, but the compliance rate was only 18.08%. Among them, 240 patients underwent additional European standard allergen tests, and positive allergens were detected in 210 cases (87.5%). Univariate analysis revealed that dosage form (emulsion and cream), age (≤ 25 years) and the allergic ingredients triethanolamine, rose oil, propylene glycol, thiomersal and musk ambrette are associated with the occurrence of cosmetic adverse reactions within seven days. A logit prediction model was also successfully constructed: Logit (P) = 1.710– 0.796× 1 + 1.185× 2 − 3.650X3-1.335X4.Conclusion: This study complements the data reported on cosmetic adverse reactions in the Chinese Han population and suggests that in future clinical ...