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In with the old! Repurposing disulfiram to target cancer stem cells (CSCs) and the root of cisplatin resistance

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • الموضوع:
      2018
    • Collection:
      Queensland University of Technology: QUT ePrints
    • نبذة مختصرة :
      Cisplatin remains the cornerstone of NSCLC management. Despite initial sensitivity tumours develop resistance, undermining the cytotoxic effect of cisplatin. Numerous mechanisms have been investigated in terms of cisplatin resistance and its development, however, the clinical issue of resistance remains. An avenue of interest is the CSC hypothesis, in which the survival and expansion of highly resistant CSCs during chemotherapy are thought to be a contributing factor of resistance. Specific inhibition of key CSC markers in combination with chemotherapy may subvert the inherent resistance of the CSCs thereby restoring therapeutic effeciency. One such CSC marker is aldehyde dehydrogenase 1 (ALDH1). We hypothesise that inhibition of the ALDH1-positive CSCs within cispaltin resistant NSCLC will resensitise the cells to cisplatin.
    • File Description:
      application/pdf
    • Relation:
      https://eprints.qut.edu.au/133377/1/133377.pdf; MacDonagh, L., Gray, S.G., Cuffe, S., Finn, S.P., Nicholson, S., Ryan, R., Young, V., Leonard, N., O?Byrne, K., & Barr, M.P. (2018) In with the old! Repurposing disulfiram to target cancer stem cells (CSCs) and the root of cisplatin resistance. In 16th Annual British Thoracic Oncology Group Conference (BTOG 2018), 2018-01-24 - 2018-01-26.; https://eprints.qut.edu.au/133377/; Faculty of Health
    • Rights:
      free_to_read ; 2019 The Author(s) ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
    • الرقم المعرف:
      edsbas.58B87967