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Do Epilepsy Patients with Cognitive Impairment Have Alzheimer’s Disease-like Brain Metabolism?

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  • معلومة اضافية
    • بيانات النشر:
      Multidisciplinary Digital Publishing Institute
    • الموضوع:
      2023
    • Collection:
      MDPI Open Access Publishing
    • نبذة مختصرة :
      Although not classically considered together, there is emerging evidence that Alzheimer’s disease (AD) and epilepsy share a number of features and that each disease predisposes patients to developing the other. Using machine learning, we have previously developed an automated fluorodeoxyglucose positron emission tomography (FDG-PET) reading program (i.e., MAD), and demonstrated good sensitivity (84%) and specificity (95%) for differentiating AD patients versus healthy controls. In this retrospective chart review study, we investigated if epilepsy patients with/without mild cognitive symptoms also show AD-like metabolic patterns determined by the MAD algorithm. Scans from a total of 20 patients with epilepsy were included in this study. Because AD diagnoses are made late in life, only patients aged ≥40 years were considered. For the cognitively impaired patients, four of six were identified as MAD+ (i.e., the FDG-PET image is classified as AD-like by the MAD algorithm), while none of the five cognitively normal patients was identified as MAD+ (χ2 = 8.148, p = 0.017). These results potentially suggest the usability of FDG-PET in prognosticating later dementia development in non-demented epilepsy patients, especially when combined with machine learning algorithms. A longitudinal follow-up study is warranted to assess the effectiveness of this approach.
    • File Description:
      application/pdf
    • Relation:
      Neurobiology and Neurologic Disease; https://dx.doi.org/10.3390/biomedicines11041108
    • الرقم المعرف:
      10.3390/biomedicines11041108
    • الدخول الالكتروني :
      https://doi.org/10.3390/biomedicines11041108
    • Rights:
      https://creativecommons.org/licenses/by/4.0/
    • الرقم المعرف:
      edsbas.55F2525E