Departamento de Farmácia, Universidade Federal de Pernambuco UFPE

This short note presents the foundations of a computer-oriented approach for preparing a list of random treatment assignments to be adopted in randomized controlled trials. Software is presented which can be applied in the earliest stage of bioavailability or bioequivalence assays. This allocation of patients to treatment in clinical trials ensures exactly equal treatment numbers. The check of the randomness properties of an assignment leads to the concept of a "strong randomized list". The new approach introduced in this note is based on thresholds and produces a strong randomized list of treatment assignments.