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Plasmodium vivax severe imported malaria in two migrants in France

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  • معلومة اضافية
    • Contributors:
      CHU Avicenne; Unité des Virus Emergents (UVE); Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); UFR Santé, Médecine et Biologie Humaine (UFR SMBH); Université Sorbonne Paris Nord; Biomolécules : Conception, Isolement, Synthèse (BioCIS); Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY); Centre National de Référence du Paludisme, hôpital Bichat-Claude Bernard; Microbiologie CHU Jean Verdier; Hôpital Jean Verdier AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
    • بيانات النشر:
      HAL CCSD
      BioMed Central
    • الموضوع:
      2019
    • Collection:
      Aix-Marseille Université: HAL
    • نبذة مختصرة :
      International audience ; BackgroundWith less than one severe case per year in average, Plasmodium vivax is very rarely associated with severe imported malaria in France. Two cases of P. vivax severe malaria occurred in patients with no evident co-morbidity. Interestingly, both cases did not occur at the primary infection but during relapses.Case presentationsPatient 1: A 27-year old male, born in Afghanistan and living in France since 2012, was admitted on August 2015 to the Avicenne hospital because of abdominal pain, intense headache, fever and hypotension. The patient was haemodynamically unstable despite 5 L of filling solution. A thin blood film showed P. vivax trophozoites within the red blood cells. To take care of the septic shock, the patient was given rapid fluid resuscitation, norepinephrine (0.5 mg/h), and intravenous artesunate. Nested polymerase chain reactions of the SSUrRNA gene were negative for Plasmodium falciparum but positive for P. vivax. The patient became apyretic in less than 24H and the parasitaemia was negative at the same time. Patient 2: A 24-year old male, born in Pakistan and living in France, was admitted on August 2016 because of fever, abdominal pain, headache, myalgia, and nausea. The last travel of the patient in a malaria endemic area occurred in 2013. A thin blood film showed P. vivax trophozoites within the red blood cells. The patient was treated orally by dihydroartemisinin-piperaquine and recovered rapidly. Nine months later, the patient returned to the hospital with a relapse of P. vivax malaria. The malaria episode was uncomplicated and the patient recovered rapidly. Three months later, the patient came back again with a third episode of P. vivax malaria. Following a rapid haemodynamic deterioration, the patient was transferred to the intensive care unit of the hospital. In all the patient received 10 L of filling solution to manage the septic shock. After 5 days of hospitalization and a specific treatment, the patient was discharged in good clinical ...
    • Relation:
      hal-02619523; https://amu.hal.science/hal-02619523; https://amu.hal.science/hal-02619523/document; https://amu.hal.science/hal-02619523/file/12936_2019_Article_3067.pdf; PUBMEDCENTRAL: PMC6916050
    • الرقم المعرف:
      10.1186/s12936-019-3067-5
    • الدخول الالكتروني :
      https://amu.hal.science/hal-02619523
      https://amu.hal.science/hal-02619523/document
      https://amu.hal.science/hal-02619523/file/12936_2019_Article_3067.pdf
      https://doi.org/10.1186/s12936-019-3067-5
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.4FE0FFE2