نبذة مختصرة : peer reviewed ; This chapter describes the concept of the hormone—Inhibin. This hormone is formed in the seminiferous tubules by Sertoli cells in males and by granulosa cells in the follicles of females. Inhibin is peptidic in nature. Its biological action is destroyed by digestion with trypsin or pepsin and by heat. It induces antibodies capable of neutralizing endogenous inhibin in adult male or female animals into which they are injected. Inhibin exerts preferential inhibition on the synthesis and release of follicle-stimulating hormone (FSH) by pituitary gonadotrophs maintained in culture. The dose requires to exert an effect on luteinizing hormone (LH) is much higher. It reduces the amount of endogenous LH-releasing hormone (RH) in the hypothalamus maintained in culture. In the intact animals, the observed effect on gonadotropin levels is the result of the action of inhibin at both sites. Inhibin has no effect on the secretion of thyroid-stimulating hormone (TSH), prolactin, or growth hormone either in vivo or in vitro. It also has an effect on gonadal function in males and females by a reduction of FSH secretion, but a direct action on the gonad also is suspected. © 1979, Academic Press Inc. All rights reserved. © 1979, Academic Press Inc.
Processing Request
No Comments.