A Study of Serum Level of Ischemia Modified Albumin in Acute Coronary Syndrome

BACKGROUND: Ischemic heart disease is the greatest single cause of mortality and loss of disability-adjusted life years worldwide. Early identification and management of patients with acute myocardial infarction reduces the mortality phenomenally. Along with ECG and other clinical parameters, cardiac biomarkers do have an important role in the early diagnosis and management of patient with ACS. This study purposes to study the role of Ischemia modified albumin as a early marker of myocardial ischemia. AIM AND OBJECTIVE: To measure Serum Ischemia Modified Albumin within 6 hours of onset of chest pain and to correlate the IMA values with CK-MB, LDH, TGL, T-CHOL, HDL, LDL & VLDL. MATERIALS AND METHODS: The study was conducted in Thanjavur Medical College Hospital. 50 patients with symptoms of acute coronary syndrome presented within 6 hours of onset of pain in the causality with ECG findings correlated and were taken as subjects. 50 age and sex matched controls were taken as control group. Blood samples were subjected to estimation of IMA (ACB test), CKMB, LDH, SGOT and lipid profile. RESULTS: The mean value of IMA for control and study group were 37.67±14.74 and 115.07±17.55 respectively. The Mann Whitney U score was .000 and p value .00 (<0.01). Spearman correlation showed significant correlation of Ischemia modified Albumin with CK-MB, lipid profile and LDH. CONCLUSION: The results of the present study confirm the findings of previous studies, that reported that the Albumin Cobalt colorimetric assay distinguishes myocardial ischemic patients from non ischemic patients (p<0.001). IMA assay presents a quantitative accurate laboratory determination of the occurrence of an Ischemic myocardial event including angina of various types. Measurement of Ischemia Modified Albumin levels diagnose Acute Coronary Syndrome in patients with ongoing myocardial ischemia in Emergency Department. Measuring IMA along with ECG and other markers improves the diagnostic sensitivity of the method.