Insuliiniresistenssin ulkoisia androgeenisia manifestaatioita

A hypothesis is created that an association between androgenetic alopecia (AGA) and serious cardiovascular events, such as myocardial infarction and fatal ischaemic heart disease has been reported, but the mechanism explaining this association has remained unclear. The aim of this study was to analyze the relationship between insulin resistance, (coronary) artery disease and AGA. Moreover, a hypothesis on the role of electromagnetic cell adhesion in the development of AGA is presented. In the present series of men aged 19–50 years (n = 154) with early (< 35 years of age), significant AGA of at least grade 3 (vertex) in the Hamilton classification modified by Norwood (Norwood 1975) was hyperinsulinaemia encountered twice as often as on age-matched controls. Other signs of the insulin resistance syndrome, such as obesity, lipid lowering and antihypertensive drugs were also found to correlate with early AGA. In a population-based case-control study, male patients living a small rural town who had undergone an urgent or elective coronary revascularization procedure (n = 85) and their age-matched controls were analysed after stratification by age at operation and hair status. The findings showed AGA to be more common coronary artery disease and early AGA as those with early coronary artery disease. In a population aged 63 years (n = 541, 217 men), neck circumference was found to correlate with the conventional anthropometric indicators of insulin resistance and with elevated serum insulin in both genders, which means that neck circumference is a simple anthropometric indicator of android type obesity and insulin resistance. In the same female population other factors of insulin resistance (whr, waist circumference, serum insulin level and microalbuminuria) were associated with marked (grade 2 or 3 on a modified Ludwig scale) hair loss. Paternal heredity was clearly characteristic of AGA in both genders, particularly of early AGA in men. We present a hypothesis that the overactive androgen state inhibits ...