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Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review

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اقرأ أكثر
  • معلومة اضافية
    • بيانات النشر:
      Elsevier
    • الموضوع:
      2018
    • Collection:
      ETH Zürich Research Collection
    • نبذة مختصرة :
      The manufacturing of recombinant protein is traditionally divided in two main steps: upstream (cell culture and synthesis of the target protein) and downstream (purification and formulation of the protein into a drug substance or drug product). Today, cost pressure, market uncertainty and market growth, challenge the existing manufacturing technologies. Leaders in the field are active in designing the process of the future and continuous manufacturing is recurrently mentioned as a potential solution to address some of the current limitations. This review focuses on the application of continuous processing to the first step of the manufacturing process. Enabling technologies and operation modes are described in the first part. In the second part, recent advances in the field that have the potential to support its successful future development are critically discussed. ; ISSN:0734-9750 ; ISSN:1873-1899
    • File Description:
      application/application/pdf
    • Relation:
      info:eu-repo/semantics/altIdentifier/wos/000435619800031; http://hdl.handle.net/20.500.11850/268594
    • الرقم المعرف:
      10.3929/ethz-b-000268594
    • الدخول الالكتروني :
      https://hdl.handle.net/20.500.11850/268594
      https://doi.org/10.3929/ethz-b-000268594
    • Rights:
      info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    • الرقم المعرف:
      edsbas.4C73168F