Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Division of Preventive Oncology Heidelberg, Germany (National Center for Tumor Diseases); German Cancer Research Center - Deutsches Krebsforschungszentrum Heidelberg (DKFZ); Team of Endocrinology and Nutrition Physiology Errachidia, Morocco; جامعة مولاي إسماعيل = Université Moulay Ismaïl (UMI)-Faculté des Sciences et Techniques d’Errachidia Errachidia, Morocco (FSTE); Centre de Recherches en Cancérologie de Toulouse (CRCT); Université Toulouse III - Paul Sabatier (UT3); Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); This study was supported by the Institut National de la Santé et de la Recherché Médicale, the Conseil Régional Midi-Pyrénées and the Institut National du Cancer through the ResisTH network. F.K. was supported by a post-doctoral fellowship from the Institut National du Cancer.
    • بيانات النشر:
      HAL CCSD
      MDPI
    • الموضوع:
      2018
    • Collection:
      Université Toulouse III - Paul Sabatier: HAL-UPS
    • نبذة مختصرة :
      International audience ; Bryonolic acid (BrA) is a pentacyclic triterpene present in several plants used in African traditional medicine such as Anisophyllea dichostyla R. Br. Here we investigated the in vitro anticancer properties of BrA. We report that BrA inhibits acyl-coA: cholesterol acyl transferase (ACAT) activity in rat liver microsomes in a concentration-dependent manner, blocking the biosynthesis of the cholesterol fatty acid ester tumour promoter. We next demonstrated that BrA inhibits ACAT in intact cancer cells with an IC50 of 12.6 ± 2.4 µM. BrA inhibited both clonogenicity and invasiveness of several cancer cell lines, establishing that BrA displays specific anticancer properties. BrA appears to be more potent than the other pentacyclic triterpenes, betulinic acid and ursolic acid studied under similar conditions. The inhibitory effect of BrA was reversed by exogenous addition of cholesteryl oleate, showing that ACAT inhibition is responsible for the anticancer effect of BrA. This report reveals new anticancer properties for BrA.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/29439506; inserm-02380570; https://inserm.hal.science/inserm-02380570; https://inserm.hal.science/inserm-02380570/document; https://inserm.hal.science/inserm-02380570/file/biomedicines-06-00021.pdf; PUBMED: 29439506; PUBMEDCENTRAL: PMC5874678
    • الرقم المعرف:
      10.3390/biomedicines6010021
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.4C62E75D