Internship Reports and Monograph Entitled 'Drug Repurposing for Skin Cancer Treatment: A Nanotechnological Approach' ; Relatórios de Estágio e Monografia Intitulada 'O Reaproveitamento de Fármacos para o Tratamento do Cancro da Pele: Uma Abordagem Nanotecnológica'

Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia ; This document includes the Internship Reports in Community Pharmacy and Drug Regulatory Affairs and the Monograph entitled “Drug Repurposing for Skin Cancer Treatment: A Nanotechnological Approach”. The internship in Community Pharmacy took place at Farmácia Nova in Luso, under the guidance of Dr. Edite Balau. The internship in Drug Regulatory Affairs took place at INFARMED I.P., under the guidance of Dr. Dina Lopes. Finally, the Monograph was prepared under the guidance of Prof. Dr. Patrícia Sofia Cabral Pires.The Internship Reports were based on the SWOT Analysis, highlighting the strengths, weaknesses, opportunities and threats that were present during both internships, which contributed to the consolidation of the knowledge acquired.Regarding the Monograph, skin cancer represents a major health concern due to its rising incidence and limited treatment options. Excessive sun exposure, among other risk factors, is mostly responsible for this cancer’s prevalence. Current treatments (surgery, chemotherapy, radiotherapy, immunotherapy, targeted therapy) often entail high costs, significant adverse effects, and patient inconvenience. The search for novel treatment options is also marked by the high capital investment and extensive development involved in the drug discovery process. In response to these challenges, a more cost-effective and patient-centered approach lies on the repurposing of existing drugs for topical application and optimizing their delivery through nanotechnology incorporation. This innovative strategy aims to take advantage of the known pharmacological background of commonly used drugs to expedite therapeutic development, direct application on the cancer tissue for localized action and diminished systemic side effects, and ultimately nanoparticle enhanced drug delivery and therapeutic efficacy. The present review dissects the different concepts involved in this approach and various works ...