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A Small Molecule that Preferentially Binds the Closed Hsp90 Conformation

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Pergamon-Elsevier Science Ltd
    • الموضوع:
      2011
    • Collection:
      UNSW Sydney (The University of New South Wales): UNSWorks
    • نبذة مختصرة :
      Article history: Received Revised Accepted Available online Described is the synthesis of 3 different fluorescein-tagged derivatives of a macrocycle, and their binding affinity to heat shock protein 90 (Hsp90). Using fluorescence polarization anisotropy, we report the binding affinity of these fluorescein-labeled compounds to Hsp90 in its open state and ATP-dependent closed state. We show that the compounds demonstrate a conformation-dependent preference for binding to the closed state.
    • Relation:
      http://hdl.handle.net/1959.4/unsworks_46839; https://doi.org/10.1016/j.bmcl.2011.09.096
    • الرقم المعرف:
      10.1016/j.bmcl.2011.09.096
    • الدخول الالكتروني :
      http://hdl.handle.net/1959.4/unsworks_46839
      https://doi.org/10.1016/j.bmcl.2011.09.096
    • Rights:
      metadata only access ; http://purl.org/coar/access_right/c_14cb ; CC-BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0/
    • الرقم المعرف:
      edsbas.4A812CDF