Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.

1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu. 2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu. 3Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany. 4Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany. 5Centre for Human Genetics, University of Marburg, Marburg, Germany. 6Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. 7NORMENT, University of Oslo, Oslo, Norway. 8Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. 9Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK. 10NIHR Maudsley BRC, King's College London, London, UK. 11Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. 12iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark. 13Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark. 14iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark. 15Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA. 16VA NY Harbor Healthcare System, Brooklyn, NY, USA. 17Research and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway. 18Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 19K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. 20Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 21Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 22Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. 23Department of Østmarka, Division of Mental Health Care, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. 24Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 25Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan. 26Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA. 27Department of Genetics, Harvard Medical School, Boston, MA, USA. 28Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia. 29Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany. 30Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 31Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 32Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 33Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 34deCODE Genetics/Amgen, Reykjavik, Iceland. 35Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway. 36Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea. 37Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation. 38Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. 39Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. 40National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark. 41Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark. 42Division of Psychiatry, University College London, London, UK. 43Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. 44Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA. 45Northwestern University, Chicago, IL, USA. 46Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, UK. 47Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. 482nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece. 49Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea. 50Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. 51Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 52Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria. 53Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway. 54Psychiatry, Brain Center UMC Utrecht, Utrecht, the Netherlands. 55Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain. 56Department of Psychiatry, Hospital Universitari Vall d´Hebron, Barcelona, Spain. 57Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. 58Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain. 59Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany. 60Psychiatry, University of California San Francisco, San Francisco, CA, USA. 61University of Newcastle, Newcastle, New South Wales, Australia. 62Mood Disorders Program, Department of Psychiatry, McGill University Health Center, Montreal, Quebec, Canada. 63Division of Psychiatry, University of Edinburgh, Edinburgh, UK. 64Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. 65Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico. 66Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA. 67Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 68Centre for Psychiatry, Queen Mary University of London, London, UK. 69UCL Genetics Institute, University College London, London, UK. 70Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland. 71Center for Multimodal Imaging and Genetics, Departments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA, USA. 72Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany. 73Department of Medical Genetics, Oslo University Hospital, Oslo, Norway. 74NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway. 75Department of Neurology, Oslo University Hospital, Oslo, Norway. 76NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway. 77Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK. 78Academic Psychiatry, Newcastle University, Newcastle upon Tyne, UK. 79Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA. 80Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 81Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA. 82Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. 83Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany. 84Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada. 85Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. 86Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA. 87Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA. 88Department of Psychological Sciences, University of Missouri, Columbia, MO, USA. 89Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 90Psychological Medicine, University of Worcester, Worcester, UK. 91Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. 92Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark. 93Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain. 94Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea. 95Landspitali University Hospital, Reykjavik, Iceland. 96Department of Psychology, Eberhard Karls Universität Tübingen, Tübingen, Germany. 97Department of Biomedicine, University of Basel, Basel, Switzerland. 98Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. 99Neuropsychiatrie Translationnelle, Inserm U955, Créteil, France. 100Faculté de Santé, Université Paris Est, Créteil, France. 101International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany. 102Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. 103Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. 104Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. 105Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. 106Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. 107Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada. 108Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany. 109Cell Biology, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA. 110Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA. 111ISGlobal, Barcelona, Spain. 112Laboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece. 113Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA. 114Center for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 115RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. 116Psychiatry, Altrecht, Utrecht, the Netherlands. 117Psychiatry, GGZ inGeest, Amsterdam, the Netherlands. 118Psychiatry, VU Medisch Centrum, Amsterdam, the Netherlands. 119Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 120Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. 121Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. 122Psychiatry, North East London NHS Foundation Trust, Ilford, UK. 123Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany. 124Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea. 125Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 126HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA. 127Department of Human Genetics, McGill University, Montréal, Quebec, Canada. 128Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec, Canada. 129Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK. 130Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. 131Clinical Biochemistry Laboratory, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. 132Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden. 133Systems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa. 134Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France. 135Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. 136Centre for Neuroimaging and Cognitive Genomics (NICOG), National University of Ireland Galway, Galway, Ireland. 137Medical Faculty, School of Science and Technology, University Sarajevo, Sarajevo, Bosnia and Herzegovina. 138Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 139Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK. 140Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK. 141Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. 142Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, the Netherlands. 143Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA. 144Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain. 145Institute of Neurosciences, Biomedical Research Center (CIBM), University of Granada, Granada, Spain. 146Medicine, Psychiatry, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. 147Department of Genetics, Microbiology and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain. 148Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 149Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK. 150Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA. 151Mood Disorders, PsyQ, Rotterdam, the Netherlands. 152SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. 153Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland. 154Neuroscience Research Australia, Sydney, New South Wales, Australia. 155School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia. 156Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid and CSIC, Madrid, Spain. 157Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, CA, USA. 158Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany. 159Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA. 160Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. 161Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. 162South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK. 163Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden. 164NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine and Diakonhjemmet Hospital, University of Oslo, Oslo, Norway. 165National Institute of Mental Health, Klecany, Czech Republic. 166Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. 167Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation. 168Department of Psychiatry, University of Münster, Münster, Germany. 169Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia. 170The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia. 171Université de Paris, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS 1144, Paris, France. 172APHP Nord, DMU Neurosciences, Département de Psychiatrie et de Médecine Addictologique, GHU Saint Louis-Lariboisière-Fernand Widal, Paris, France. 173Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. 174Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. 175Department of Biomedicine and the iSEQ Center, Aarhus University, Aarhus, Denmark. 176Center for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark. 177School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia. 178University of Queensland, Brisbane, Queensland, Australia. 179Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. 1801st Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece. 181Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. 182Division of Endocrinology, Children's Hospital Boston, Boston, MA, USA. 183Department of Human Genetics, University of Chicago, Chicago, IL, USA. 184Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania. 185HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. 186University of Western Australia, Nedlands, Western Australia, Australia. 187Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. 188Department of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, France. 189Department of Medical and Molecular Genetics, King's College London, London, UK. 190Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA. 191Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. 192SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. 193School of Psychology, The University of Queensland, Brisbane, Queensland, Australia. 194Department of Psychiatry and Genetics Institute, University of Florida, Gainesville, FL, USA. 195Research Institute, Lindner Center of HOPE, Mason, OH, USA. 196Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. 197Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA. 198Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo, Norway. 199Psychiatry, St Olavs University Hospital, Trondheim, Norway. 200Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Risskov, Denmark. 201Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. 202University of Liverpool, Liverpool, UK. 203Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. 204Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark. 205Division of Psychiatry, Haukeland Universitetssjukehus, Bergen, Norway. 206Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway. 207Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden. 208Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA. 209University of Melbourne, Melbourne, Victoria, Australia. 210Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates. 211Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates. 212Psychiatry, Harvard Medical School, Boston, MA, USA. 213Division of Clinical Research, Massachusetts General Hospital, Boston, MA, USA. 214Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. 215Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, the Netherlands. 216Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. 217Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA. 218Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy. 219Department of Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA. 220Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA. 221Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 222Department of Psychiatry, Hospital Namsos, Namsos, Norway. 223Department of Neuroscience, Norges Teknisk Naturvitenskapelige Universitet Fakultet for Naturvitenskap og Teknologi, Trondheim, Norway. 224Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 225Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 226Department of Psychiatry, McGill University, Montreal, Quebec, Canada. 227Department of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway. 228Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain. 229Department of Psychology, Emory University, Atlanta, GA, USA. 230Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark. 231Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 232Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark. 233Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. 234Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. 235Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. 236Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. 237Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. ole.andreassen@medisin.uio.no. 238NORMENT, University of Oslo, Oslo, Norway. ole.andreassen@medisin.uio.no. #Contributed equally.

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https://www.nature.com/articles/s41588-021-00857-4; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192451/; Mullins N, Forstner AJ, O'Connell KS, et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nat Genet. 2021;53(6):817-829. doi:10.1038/s41588-021-00857-4; http://hdl.handle.net/2336/621998; Nature genetics

10.1038/s41588-021-00857-4

https://doi.org/10.1038/s41588-021-00857-4
http://hdl.handle.net/2336/621998

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