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Prevalence of gastrointestinal pathogenic bacteria in patients with diarrhoea attending Groote Schuur Hospital, Cape Town, South Africa

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      National Research Foundation of South Africa; Carnegie Corporation; Claude Leon Foundation
    • بيانات النشر:
      South African Medical Association
    • الموضوع:
      2015
    • Collection:
      South African Medical Journal (SAMJ)
    • الموضوع:
      Groote Schuur Hospital; Adult patients with diarrhoea
    • الموضوع:
      2012
    • نبذة مختصرة :
      Background. Diarrhoea due to gastrointestinal infections is a significant problem facing the South African (SA) healthcare system. Infections can be acquired both from the community and from the hospital environment itself, the latter acting as a reservoir for potential pathogenic bacteria.Objectives. To examine the prevalence of a panel of potential diarrhoea-causing bacteria in patients attending a tertiary healthcare facility in Cape Town, SA.Methods. Polymerase chain reaction (PCR) primers specific for Clostridium difficile, Shigella spp., Salmonella spp., Klebsiella oxytoca, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC/EHEC), Staphylococcus aureus, enterotoxigenic Bacteroides fragilis and Campylobacter spp. were used to screen total bacterial genomic DNA extracted from stool samples provided by 156 patients with diarrhoea attending Groote Schuur Hospital, Cape Town, SA.Results. C. difficile was the most frequently detected pathogen (16% of cases) in the 21 - 87-year-old patient range, but was not present in samples from the 16 - 20-year-old range. K. oxytoca (6%), EPEC/EHEC strains (9%) and S. aureus (6%) were also detected. The remaining pathogens were present at low frequencies (0 - 2.9%), and the occurrence of mixed infections was 5%. The majority of non-C. difficile-related diarrhoeas were community acquired.Conclusion. C. difficile was the main cause of infectious diarrhoea in the sampled patients, while K. oxytoca and EPEC/EHEC strains were present as relatively minor but potentially significant pathogens.
    • File Description:
      application/pdf
    • Relation:
      http://samj.org.za/index.php/samj/article/view/8654/6544; http://samj.org.za/index.php/samj/article/downloadSuppFile/8654/6739; http://samj.org.za/index.php/samj/article/downloadSuppFile/8654/6727; http://samj.org.za/index.php/samj/article/view/8654
    • الرقم المعرف:
      10.7196/SAMJ.8654
    • الدخول الالكتروني :
      http://samj.org.za/index.php/samj/article/view/8654
      https://doi.org/10.7196/SAMJ.8654
    • Rights:
      Copyright of published material remains in the Authors’ name. This allows authors to use their work for their own non-commercial purposes without seeking permission from the Publisher, subject to properly acknowledging the Journal as the original place of publication. Authors are free to copy, print and distribute their articles, in full or in part, for teaching activities, and to deposit or include their work in their own personal or institutional database or on-line website. Authors are requested to inform the Journal/Publishers of their desire/intention to include their work in a thesis or dissertation or to republish their work in any derivative form (but not for commercial use). Material submitted for publication in the SAMJ is accepted provided it has not been published or submitted for publication elsewhere. Please inform the editorial team if the main findings of your paper have been presented at a conference and published in abstract form, to avoid copyright infringement.
    • الرقم المعرف:
      edsbas.49924469