Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

HIV RNA Load and Antiretroviral Drug Resistance of HIV-1 Strains in Chad on Dried Blood Spots: A Pilot Study

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Département des maladies infectieuses, CHU Walia, Hôpital Le Bon Samaritain, N’Djamena, Tchad; Institut National de Recherche en Santé Publique Bamako (INRSP); Physiopathologie et biothérapies des infections muqueuses CIRI (CIRI-GIMAP); Centre International de Recherche en Infectiologie (CIRI); École normale supérieure de Lyon (ENS de Lyon); Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon); Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Service des Agents Infectieux et Hygiène CHU Saint-Etienne; Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM); Laboratoire de Virologie Médicale et Moléculaire, Centre Hospitalier Universitaire, Reims, France.; Hôpital universitaire Robert Debré Reims (CHU Reims)
    • بيانات النشر:
      CCSD
    • الموضوع:
      2021
    • Collection:
      HAL Lyon 1 (University Claude Bernard Lyon 1)
    • نبذة مختصرة :
      International audience ; We performed viral load (VL) and antiretroviral (ARV) drug resistance genotyping assays using dried blood spot samples (DBS) taken from HIV-1 infected patients in Chad. Among 80 adult patients naïve of any antiretroviral treatment regimen, 67 (84%) had a measured VL upper than 40 copies/ml (median; SD: 36891 copies/ml; [603-2 798 968]) of blood. Of them only 24 (36%) demonstrating a viral load upper was than 3.63 log 10 copies/ml were successfully sequenced for performing a drug resistance genotyping assay. Of the 24 patients whom DBS samples were successfully sequenced, seven (29%) displayed the presence of an HIV-1 strain with known mutations conferring resistance against at least one ARV family. Our pilot study provides major data on the high prevalence levels of primary resistance to available ARV drugs in HIV-1 infected patients in Chad and highlights the need for a wide and rational use of HIV anti-integrase drugs in Sahelian area.
    • الرقم المعرف:
      10.33696/AIDS.3.014
    • الدخول الالكتروني :
      https://hal.science/hal-04936765
      https://hal.science/hal-04936765v1/document
      https://hal.science/hal-04936765v1/file/article-pdf-1664442501-711.pdf
      https://doi.org/10.33696/AIDS.3.014
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.47586A1F