Identification of peroxisome proliferator response element (PPRE) in a novel peroxisome proliferator-activated receptor regulating gene, peroxisome proliferator and starvation-induced gene (PPSIG).

Ng Lui. ; Thesis (M.Phil.)--Chinese University of Hong Kong, 2006. ; Includes bibliographical references (leaves 243-257). ; Abstracts in English and Chinese. ; Abstract --- p.i_iii ; Abstract (Chinese version) --- p.iv-v ; Acknowledgements --- p.vi ; Table of Contents --- p.vii-xvii ; List of Abbreviations --- p.xviii-xx ; List of Figures --- p.xxi-xxvi ; List of Tables --- p.xxvii ; Chapter Chapter 1 --- Introduction --- p.1 ; Chapter 1.1 --- Peroxisome Proliferators (PPs) --- p.1 ; Chapter 1.2 --- Peroxisome proliferator-activated receptors (PPARs) --- p.3 ; Chapter 1.2.1 --- What are PPARs? --- p.3 ; Chapter 1.2.2 --- PPAR isoforms --- p.3 ; Chapter 1.2.2.1 --- PPARp/δ --- p.3 ; Chapter 1.2.2.2 --- PPARγ --- p.4 ; Chapter 1.2.2.3 --- PPARα --- p.5 ; Chapter 1.2.3 --- PPARα target genes --- p.5 ; Chapter 1.2.3.1 --- Transcriptional regulation --- p.5 ; Chapter 1.2.3.2 --- PPRE --- p.6 ; Chapter 1.2.4 --- Physiological roles --- p.9 ; Chapter 1.2.4.1 --- Lipid metabolism --- p.9 ; Chapter 1.2.4.1.1 --- Cellular fatty acid uptake and fatty acid activation --- p.9 ; Chapter 1.2.4.1.2 --- Intracellular fatty acid transport --- p.11 ; Chapter 1.2.4.1.3 --- Mitochondrial fatty acid uptake --- p.12 ; Chapter 1.2.4.1.4 --- Mitochondrial fatty-acid P-oxidation ; Chapter 1.2.4.1.5 --- Peroxisomal fatty acid uptake --- p.13 ; Chapter 1.2.4.1.6 --- Peroxisomal fatty acid oxidation --- p.13 ; Chapter 1.2.4.1.7 --- Micorsomal co-hydroxylation of fatty acids --- p.14 ; Chapter 1.2.4.1.8 --- Ketogenesis --- p.15 ; Chapter 1.2.4.1.9 --- Bile acid metabolism --- p.15 ; Chapter 1.2.4.1.10 --- Lipoprotein metabolism --- p.17 ; Chapter 1.2.4.1.11 --- Hepatic lipogenesis --- p.18 ; Chapter 1.2.4.2 --- Glucose metabolism --- p.19 ; Chapter 1.2.4.2.1 --- Glycogenolysis --- p.19 ; Chapter 1.2.4.2.2 --- Glycolysis --- p.20 ; Chapter 1.2.4.2.3 --- Gluconeogenesis --- p.20 ; Chapter 1.2.4.3 --- Urea cycle --- p.21 ; Chapter 1.2.4.4 --- Biotransformation --- p.22 ; Chapter 1.2.4.5 --- Inflammation --- p.23 ; Chapter 1.2.4.6 --- Acute ...