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Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with disease severity in COVID-19
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- المؤلفون: Zhang, Y; Qin, L; Zhao, Y; Zhang, P; Xu, B; Li, K; Liang, L; Zhang, C; Dai, Y; Feng, Y; Sun, J; Hu, Z; Xiang, H; Knight, JC; Dong, T; Jin, R
- نوع التسجيلة:
article in journal/newspaper
- اللغة:
English
- معلومة اضافية
- بيانات النشر:
Oxford University Press
- الموضوع:
2020
- Collection:
Oxford University Research Archive (ORA)
- نبذة مختصرة :
A major unanswered question in the current global COVID-19 outbreak is why a small minority of infected individuals develop severe disease. Here we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at risk individuals.
- Relation:
https://ora.ox.ac.uk/objects/uuid:a31279fe-da98-4310-8feb-ee4cef7e4eba; https://doi.org/10.1093/infdis/jiaa224
- الرقم المعرف:
10.1093/infdis/jiaa224
- Rights:
info:eu-repo/semantics/openAccess ; CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)
- الرقم المعرف:
edsbas.446915A2
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