نبذة مختصرة : The increasing number of people with dementia globally illustrates the urgent need to reduce dementia's scale and impact. Lifetime social participation may affect dementia risk by increasing cognitive reserve, and through brain maintenance by reducing stress and improving cerebrovascular health. It may therefore have important implications for individual behavior and public health policy aimed at reducing dementia burden. Observational study evidence indicates that greater social participation in midlife and late life is associated with 30-50% lower subsequent dementia risk, although some of this may not be causal. Social participation interventions have led to improved cognition but, partly due to short follow-up and small numbers of participants, no reduction in risk of dementia. We summarize the evidence linking social participation with dementia, discuss potential mechanisms by which social participation is likely to reduce and mitigate the impact of neuropathology in the brain, and consider the implications for future clinical and policy dementia prevention interventions.This Review provides evidence-based update on the association between social interaction and risk of dementia. The authors propose a policy framework to promote social interaction as a preventative strategy against dementia. ; Peer reviewed
Relation: This research was funded in whole, or in part, by the Wellcome Trust (222932/Z/21/Z). For the purpose of open access, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission. A.S. and G.L. are supported by the University College London Hospitals National Institute for Health Research (NIHR) Biomedical Research Centre and funded by the NIHR ENHANCE study (NIHR203670). M.K. was supported by the Wellcome Trust (221854/Z/20/Z), the UK Medical Research Council (MRC; S011676/1, R024227/1), the US National Institute on Aging (R01AG056477) and the Academy of Finland (350426). E.B.L. is supported by research grants from the US National Institute on Aging (UO1AG0006781, RO1AG). S.R. is a Global Atlantic Fellow for Equity in Brain Health and supported by the Global Brain Health Institute. A.S.-M. is supported by grants from the National Institute on Aging, National Institutes of Health (R01AG056477, RF1AG062553). G.L. is supported by NIHR ARC and is an NIHR senior investigator.; Sommerlad , A , Kivimäki , M , Larson , E B , Röhr , S , Shirai , K , Singh-Manoux , A & Livingston , G 2023 , ' Social participation and risk of developing dementia ' , Nature Aging , vol. 3 , no. 5 , pp. 532-545 . https://doi.org/10.1038/s43587-023-00387-0; http://hdl.handle.net/10138/572911; 59026360-602f-4914-9746-746e522ad4f0; 000992434000010
Processing Request
No Comments.