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Genetic polymorphisms of Th2 interleukins, history of asthma or eczema and childhood acute lymphoid leukaemia: Findings from the ESCALE study (SFCE)

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  • معلومة اضافية
    • Contributors:
      Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent (CRESS - U1153); Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)); Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM); Registre National des Cancers de l'Enfant - National Registry of Childhood Cancers Villejuif & CHU Nancy (RNCE); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM); London School of Hygiene and Tropical Medicine (LSHTM); CHU Trousseau APHP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); AP-HP Hôpital universitaire Robert-Debré Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Institut d'hématologie et d'oncologie pédiatrique CHU - HCL (IHOPe); Hospices Civils de Lyon (HCL); Hôpital Jeanne de Flandres; Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Hôpital de la Timone CHU - APHM (TIMONE); Hôpital Arnaud de Villeneuve CHRU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Université de Montpellier (UM); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Hôpital Pellegrin; CHU Bordeaux-Groupe hospitalier Pellegrin; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Centre National de Génotypage (CNG); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
    • بيانات النشر:
      HAL CCSD
      Elsevier
    • الموضوع:
      2018
    • Collection:
      Inserm: HAL (Institut national de la santé et de la recherche médicale)
    • نبذة مختصرة :
      International audience ; BACKGROUND:Previous studies on the putative role of allergy in the aetiology of childhood leukaemia have reported contradictory results. The present study aimed to analyse the relation between a medical history of asthma or eczema and childhood acute lymphoid leukaemia (ALL) in light of potential candidate gene-environment interactions.METHODS:Analyses were based on a subset of 434 cases of ALL and 442 controls successfully genotyped and of European ancestry children enrolled in a French population-based case-control study conducted in 2003-2004. Information about medical history was obtained during a standardized interview with the mothers. Candidate polymorphisms in genes of the Th2 cytokines IL4, IL10, IL13 and IL4-receptor, were genotyped or imputed.RESULTS:None of the variant alleles were directly associated with childhood acute lymphoid leukaemia. A medical history of asthma or eczema was reported more often in the control group (OR = 0.7 [0.5-1.0]). This association was mostly seen in the group of children not carrying the IL13-rs20541 variant allele (Interaction Odds Ratio IOR 1.9, p-interaction = 0.07) and in those carrying the IL10 triple variant haplotype (IOR 0.5, p-interaction = 0.04). No interaction was observed with the candidate polymorphisms in IL4 and IL4R.CONCLUSION:This study provides a new insight into the relationship between allergic symptoms and childhood acute lymphoid leukaemia, by suggesting this inverse association could be limited to children carrying certain genetic polymorphisms. If confirmed, these results could help better understand the biological mechanisms involved in the development of childhood acute lymphoid leukaemia.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/29883839; hal-02319684; https://hal.umontpellier.fr/hal-02319684; https://hal.umontpellier.fr/hal-02319684/document; https://hal.umontpellier.fr/hal-02319684/file/Genetic-polymorphisms-of-Th2-interleukins-history-of-asthma-or-eczema-and-childhood-acute-lymphoid-leukaemia.pdf; PUBMED: 29883839
    • الرقم المعرف:
      10.1016/j.canep.2018.05.004
    • الدخول الالكتروني :
      https://hal.umontpellier.fr/hal-02319684
      https://hal.umontpellier.fr/hal-02319684/document
      https://hal.umontpellier.fr/hal-02319684/file/Genetic-polymorphisms-of-Th2-interleukins-history-of-asthma-or-eczema-and-childhood-acute-lymphoid-leukaemia.pdf
      https://doi.org/10.1016/j.canep.2018.05.004
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.41BA50EC