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Optimal control strategies to tailor antivirals for acute infectious diseases in the host

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Cornell University
    • Collection:
      CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas)
    • نبذة مختصرة :
      Several mathematical models in SARS-CoV-2 have shown how target-cell model can help to understand the spread of the virus in the host and how potential candidates of antiviral treatments can help to control the virus. Concepts as equilibrium and stability show to be crucial to qualitative determine the best alternatives to schedule drugs, according to effectivity in inhibiting the virus infection and replication rates. Important biological events such as rebounds of the infections (when antivirals are incorrectly interrupted) can also be explained by means of a dynamic study of the target-cell model. In this work a full characterization of the dynamical behavior of the target-cell models under control actions is made and, based on this characterization, the optimal fixeddose antiviral schedule that produces the smallest amount of dead cells (without viral load rebounds) is computed. Several simulation results - performed by considering real patient data - show the potential benefits of both, the model characterization and the control strategy. ; Fil: Perez, Mara Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina ; Fil: Abuin, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina ; Fil: Actis, Marcelo Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina ; Fil: Ferramosca, Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Università Degli Studi Di Bergamo; Italia ; Fil: ...
    • File Description:
      application/pdf
    • ISSN:
      2331-8422
    • Relation:
      info:eu-repo/semantics/altIdentifier/arxiv/https://arxiv.org/abs/2106.09528; info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/B9780323901710000111; http://hdl.handle.net/11336/167735; Perez, Mara Isabel; Abuin, Pablo; Actis, Marcelo Jesús; Ferramosca, Antonio; Hernandez Vargas, Esteban Abelardo; et al.; Optimal control strategies to tailor antivirals for acute infectious diseases in the host; Cornell University; ArXiv.org; 6-2021; 1-26; CONICET Digital; CONICET
    • Rights:
      info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
    • الرقم المعرف:
      edsbas.410BF045