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Impact of transperineal ultrasound on perineal skin dose in prostate radiation therapy

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  • معلومة اضافية
    • بيانات النشر:
      Elsevier
    • الموضوع:
      2022
    • Collection:
      Queensland University of Technology: QUT ePrints
    • نبذة مختصرة :
      Introduction: This study investigated the relationship between anatomical compression introduced via ultrasound probe pressure and maximum perineum dose in prostate radiotherapy patients using the Clarity transperineal ultrasound (TPUS) system. Methods: 115 patient ultrasound and computed tomography scans were retrospectively analysed. The probe to prostate apex distance (PPA), probe to inferior corpus spongiosum distance (PICS) and maximum perineum dose were calculated. Compression was represented by the PICS and the calculated corpus to prostate ratio (CPR). Demographics included treatment technique, image quality, body mass index (BMI) and age. Multiple linear regression analysis assessed the relationship between compression measures and perineum dose. Results: The maximum dose to perineum ranged from 1.81 to 45.56 Gy, with a median of 5.87 Gy (Interquartile range (IQR) 3.17). The PICS distance and CPR recorded was 1.67 cm (IQR 0.63) and 0.51 (range 0.29–0.85) respectively. Regression analysis demonstrated both PICS and CPR were significant predictors of maximum dose to the perineum (p < 0.001). Patient-specific factors, including age, BMI, treatment technique and ultrasound image quality, were not factors that significantly impacted the maximum perineum dose. Conclusion: There was a statistically significant association between increased anatomical compression and perineal dose measurements. A PICS of 1.2 cm or greater is recommended, with compression reduced as much as possible without losing anatomical US definition. Future investigations would be beneficial to evaluate the optimal balance between ultrasound image quality and transducer compression considering the perineum dose.
    • File Description:
      application/pdf
    • Relation:
      https://eprints.qut.edu.au/234998/8/114863213.pdf; De Silva, Kalani, Brown, Amy, & Edwards, Christopher (2022) Impact of transperineal ultrasound on perineal skin dose in prostate radiation therapy. Technical Innovations & Patient Support in Radiation Oncology, 23, pp. 27-32.; https://eprints.qut.edu.au/234998/; Centre for Biomedical Technologies; Faculty of Engineering; Faculty of Health; School of Clinical Sciences
    • الدخول الالكتروني :
      https://eprints.qut.edu.au/234998/
    • Rights:
      free_to_read ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; 2022 The Author(s) ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
    • الرقم المعرف:
      edsbas.405086B9