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The effect of chronic peripheral nesfatin-1 application on blood pressure in normal and chronic restraint stressed rats: Related with circulating level of blood pressure regulators

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  • معلومة اضافية
    • بيانات النشر:
      Slovak Academy of Sciences
    • الموضوع:
      2015
    • Collection:
      Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi
    • نبذة مختصرة :
      Nesfatin is a peptide secreted by peripheral tissues, central and peripheral nervous system. It is involved in the regulation of homeostasis. Although the effects of nesfatin-1 on nutrition have been studied widely in the literature, the mechanisms of nesfatin-1 action and also relations with other physiological parameters are still not clarified well. We aimed to investigate the effect of peripheral chronic nesfatin-1 application on blood pressure regulation in normal and in rats exposed to restraint immobilization stress. In our study, three month-old male Wistar rats were used. Rats were divided into 4 groups as Control, Stress, Control+Nesfatin-1, Nesfatin-1+Stress. Angiotensinogen, angiotensin converting enzyme 2, angiotensin II, endothelin-1, endothelial nitric oxide synthase, aldosterone, cortisol, nesfatin-1 levels were determined in plasma samples by ELISA. Our results have shown that chronic peripheral nesfatin-1 administration increases blood pressure in normal and in rats exposed to chronic restraint stress. Effect of nesfatin-1 on circulating level of angiotensinogen, angiotensin converting enzyme 2, angiotensin II, endothelin-1, endothelial nitric oxide synthase, aldosterone and cortisol has been identified. We can conclude that elevated high blood pressure after chronic peripheral nesfatin-1 administration in rats exposed to chronic restraint stress may be related to decreased plasma level of endothelial nitric oxide synthase concentration.
    • ISSN:
      0231-5882
      25504061
    • Relation:
      General Physiology and Biophysics; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/10394; https://doi.org/10.4149/gpb_2014032; 34; 81; 88; 2-s2.0-84925358280; WOS:000349585000010
    • الرقم المعرف:
      10.4149/gpb_2014032
    • الدخول الالكتروني :
      https://hdl.handle.net/11499/10394
      https://doi.org/10.4149/gpb_2014032
    • Rights:
      open
    • الرقم المعرف:
      edsbas.3F83A899