Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract from Phoenix dactylifera L. Parthenocarpic Dates

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Laboratory of Plant Biotechnology Sfax; Faculté des Sciences de Sfax (FSS); Université de Sfax - University of Sfax-Université de Sfax - University of Sfax; Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08); Institut Pasteur de Tunis; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP); Université de Tunis El Manar (UTM); This research was supported by the Ministry of Higher Education and Scientific Research in Tunisia.; The major part of this work was accomplished at the Faculty of Sciences of Sfax and at the Institute Pasteur of Tunis. The authors gratefully acknowledge the support of Mr. El Abed Mokhles for his assistance in the project.
    • بيانات النشر:
      HAL CCSD
      Hindawi Publishing Corporation
    • الموضوع:
      2018
    • Collection:
      Réseau International des Instituts Pasteur, Paris: HAL-RIIP
    • نبذة مختصرة :
      International audience ; The aim of this study was to evaluate the antioxidant, the anti-inflammatory, and the antitumoral activities of the aqueous ethanolic extract from Phoenix dactylifera L. parthenocarpic dates. The antioxidant activity was carried using DPPH radical scavenging activity. The result showed that parthenocarpic dates had strongly scavenging activity on DPPH reaching 94% with an IC 50 value of 0.15 ± 0.011 mg/mL (p < 0.05). The anti-inflammatory potential was determined by the inhibitory effect of the aqueous ethanolic extract on phospholipase A 2 activity as well as on carrageenan-induced paw oedema in mice. The in vitro study showed that the extract inhibited the phospholipase A 2 activity with an IC 50 value of 130 í µí¼g/mL and the in vivo study showed a significantly decrease in the paw oedema after 1 h compared to the control group. Finally, the antiproliferative activity of the aqueous ethanolic extract was assessed by MTT test against MCF-7 and MDA-MB-231 cancer cell lines. This extract was effective in inhibiting MDA-MB-231 and MCF-7 cancer cells growth with IC 50 values of 8 and 18 mg/mL, respectively, after 72 h treatment. These results confirm the ethnopharmacological significance of Phoenix dactylifera L. parthenocarpic dates, which could add support for its pharmaceutical use.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/30175115; pasteur-01990509; https://riip.hal.science/pasteur-01990509; https://riip.hal.science/pasteur-01990509/document; https://riip.hal.science/pasteur-01990509/file/Antioxidant,%20Anti-Inflammatory.pdf; PUBMED: 30175115; PUBMEDCENTRAL: PMC6106911
    • الرقم المعرف:
      10.1155/2018/1542602
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.3EB2A23C