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Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • الموضوع:
      2011
    • Collection:
      Universidad de Chile: Repositorio académico
    • نبذة مختصرة :
      Background: Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined. Results: The amplification of a housekeeping gene showed that 46/55 samples (84%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7%) and EBV was detected in 3/46 (6.5%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013). Conclusions: The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC. © 2011 Agu
    • File Description:
      application/pdf
    • ISSN:
      17509378
    • Relation:
      Infectious Agents and Cancer, Volumen 6, Issue 1, 2018; https://repositorio.uchile.cl/handle/2250/165266
    • الرقم المعرف:
      10.1186/1750-9378-6-7
    • الدخول الالكتروني :
      https://doi.org/10.1186/1750-9378-6-7
      https://repositorio.uchile.cl/handle/2250/165266
    • Rights:
      Attribution-NonCommercial-NoDerivs 3.0 Chile ; http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
    • الرقم المعرف:
      edsbas.3CAA22AF