Contributors: University of Ibadan; University College Hospital Ibadan, Nigeria; Neuroépidémiologie Tropicale (NET); CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST); Université de Limoges (UNILIM)-Université de Limoges (UNILIM); Université de Lagos; Université de Yaoundé I (UY1); Kwame Nkrumah University of Science and Technology (KNUST); Korle-BU Teaching Hospital Accra (KBTH); Université de Parakou = University of Parakou (UP); Newcastle University Newcastle; University of Nairobi; Department of Earth Sciences Addis Ababa; Addis Ababa University (AAU); University of Dodoma Tanzanie (UDOM); Université du Botswana; Division of Clinical Pharmacology Cape Town, South Africa (Department of Medicine); University of Cape Town; Lawson Health Research Institute London (ON) Canada; Faculté de Médecine Université Eduardo Mondlane; Université Eduardo Mondlane = Eduardo Mondlane University = Universidade Eduardo Mondlane (UEM); University of Texas Health Science Center at San Antonio San Antonio, Tx, USA; John P. Hussman Institute for Human Genomics; University of Miami Leonard M. Miller School of Medicine (UMMSM); Trinity College Dublin; University of California San Francisco (UC San Francisco); University of California (UC)
نبذة مختصرة : International audience ; In tandem with the ever-increasing aging population in low and middle-income countries, the burden of dementia is rising on the African continent. Dementia prevalence varies from 2.3% to 20.0% and incidence rates are 13.3 per 1000 person-years with increasing mortality in parts of rapidly transforming Africa. Differences in nutrition, cardiovascular factors, comorbidities, infections, mortality, and detection likely contribute to lower incidence. Alzheimer's disease, vascular dementia, and human immunodeficiency virus/acquired immunodeficiency syndrome-associated neurocognitive disorders are the most common dementia subtypes. Comprehensive longitudinal studies with robust methodology and regional coverage would provide more reliable information. The apolipoprotein E (APOE) ε4 allele is most studied but has shown differential effects within African ancestry compared to Caucasian. More candidate gene and genome-wide association studies are needed to relate to dementia phenotypes. Validated culture-sensitive cognitive tools not influenced by education and language differences are critically needed for implementation across multidisciplinary groupings such as the proposed African Dementia Consortium.
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