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Live birth rate after female fertility preservation for cancer or haematopoietic stem cell transplantation: a systematic review and meta-analysis of the three main techniques; embryo, oocyte and ovarian tissue cryopreservation

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  • معلومة اضافية
    • Contributors:
      Hôpital Femme Mère Enfant CHU - HCL (HFME); Hospices Civils de Lyon (HCL); Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (SBRI); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Université de Montpellier (UM); Hôpital Universitaire Carémeau Nîmes (CHU Nîmes); Centre Hospitalier Universitaire de Nîmes (CHU Nîmes); Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon); Clinique La Croix du Sud; Imagerie Moléculaire et Stratégies Théranostiques (IMoST); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA); CHU Estaing Clermont-Ferrand; CHU Clermont-Ferrand; Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE); Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement IRD : UMR237-Centre National de la Recherche Scientifique (CNRS); Hôpital de la Conception CHU - APHM (LA CONCEPTION)
    • بيانات النشر:
      HAL CCSD
      Oxford University Press (OUP)
    • الموضوع:
      2022
    • Collection:
      Inserm: HAL (Institut national de la santé et de la recherche médicale)
    • نبذة مختصرة :
      International audience ; STUDY QUESTION What are the chances of achieving a live birth after embryo, oocyte and ovarian tissue cryopreservation (OTC) in female cancer survivors? SUMMARY ANSWER The live birth rates (LBRs) following embryo and oocyte cryopreservation are 41% and 32%, respectively, while for IVF and spontaneous LBR after tissue cryopreservation and transplantation, these rates are 21% and 33%, respectively. WHAT IS KNOWN ALREADY Currently, fertility preservation (FP) has become a major public health issue as diagnostic and therapeutic progress has made it possible to achieve an 80% survival rate in children, adolescents and young adults with cancer. In the latest ESHRE guidelines, only oocyte and embryo cryopreservation are considered as established options for FP. OTC is still considered to be an innovative method, while it is an acceptable FP technique in the American Society for Reproductive Medicine guidelines. However, given the lack of studies on long-term outcomes after FP, it is still unclear which technique offers the best chance to achieve a live birth. STUDY DESIGN, SIZE, DURATION We performed a systematic review and meta-analysis of published controlled studies. Searches were conducted from January 2004 to May 2021 in Medline, Embase and the Cochrane Library using the following search terms: cancer, stem cell transplantation, FP, embryo cryopreservation, oocyte vitrification, OTC and reproductive outcome. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 126 full-text articles were preselected from 1436 references based on the title and abstract and assessed via the Newcastle–Ottawa Quality Assessment Scale. The studies were selected, and their data were extracted by two independent reviewers according to the Cochrane methods. A fixed-effect meta-analysis was performed for outcomes with high heterogeneity. MAIN RESULTS AND THE ROLE OF CHANCE Data from 34 studies were used for this meta-analysis. Regarding cryopreserved embryos, the LBR after IVF was 41% (95% CI: 34–48, I2: 0%, fixed ...
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/36421038; hal-03932411; https://hal.science/hal-03932411; https://hal.science/hal-03932411/document; https://hal.science/hal-03932411/file/FRAISON%20et%20al%202022.pdf; PUBMED: 36421038
    • الرقم المعرف:
      10.1093/humrep/deac249
    • Rights:
      http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.3B5A678C