نبذة مختصرة : Sleep is an important contributor for neural maturation and emotion regulation during adolescence, with long-term effects on a range of white matter tracts implicated in affective processing in at-risk populations. We investigated the effects of adolescent sleep patterns on longitudinal changes in white matter development and whether this is related to the emergence of emotional (internalizing) problems. Sleep patterns and internalizing problems were assessed using self-report questionnaires in adolescents recruited in the general population followed up from age 14-19 years (N = 111 White matter structure was measured using diffusion tensor imaging (DTI) and estimated using fractional anisotropy (FA). We found that longitudinal increases in time in bed (TIB) on weekends and increases in TIB-variability between weekdays to weekend, were associated with an increase in FA in various interhemispheric and cortico-striatal tracts. Extracted FA values from left superior longitudinal fasciculus mediated the relationship between increases in TIB on weekends and a decrease in internalizing problems. These results imply that while insufficient sleep might have potentially harmful effects on long-term white matter development and internalizing problems, longer sleep duration on weekends (catch-up sleep) might be a natural counteractive and protective strategy. ; Peer reviewed
Relation: This work received support from the following sources: the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology) (LSHM-CT-2007-037286), the Horizon 2020 funded ERC Advanced Grant 'STRATIFY' (Brain network based stratification of reinforcement-related disorders) (695313), Human Brain Project (HBP SGA 2, 785907, and HBP SGA 3, 945539), the Medical Research Council Grant c-VEDA (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1), the National Institute of Health (NIH) (R01DA049238, A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers), the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, the Bundesministerium fuer Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; Forschungsnetz AERIAL 01EE1406A, 01EE1406B; Forschungsnetz IMAC-Mind 01GL1745B), the Deutsche Forschungsgemeinschaft (DFG grants SM 80/7-2, SFB 940, TRR 265, NE 1383/14-1), the Medical Research Foundation and Med-ical Research Council (grants MR/R00465X/1 and MR/S020306/1), the National Institutes of Health (NIH) funded ENIGMA (grants 5U54EB020403-05 and 1R56AG058854-01). Further support was provided by grants from: -the ANR (ANR-12-SAMA-0004, AAPG2019-GeBra), the Eranet Neuron (AF12-NEUR0008-01-WM2NA; and ANR-18-NEUR00002-01 -ADORe), the Fondation de France (00081242), the Fondation pour la Recherche Me'dicale (DPA20140629802), the Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hopitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012, the Fonda-tion de l'Avenir (grant AP-RM-17-013), the Federation pour la Recherche sur le Cerveau; the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), U.S.A. (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772-01A1), and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence. The Academy of Finland (grant number 276612 to A.S.S); the Emil Aaltonen Foundation (grant to A.S.S.); the Jalmari and Rauha Ahokas Foundation (grant to A. S.S). The INSERM, and the Strasbourg University and SATT CONECTUS, provided sponsorship (PI: Jean-Luc Martinot).; Guldner , S , Sarvasmaa , A S , Lemaitre , H , Massicotte , J , Vulser , H , Miranda , R , Bezivin-Frere , P , Filippi , I , Penttilä , J , Banaschewski , T , Barker , G J , Bokde , A L W , Bromberg , U , Buechel , C , Conrod , P J , Desrivieres , S , Flor , H , Frouin , V , Gallinat , J , Garavan , H , Gowland , P , Heinz , A , Nees , F , Papadopoulos-Orfanos , D , Smolka , M N , Schumann , G , Artiges , E , Martinot , M-L P & Martinot , J-L 2023 , ' Longitudinal associations between adolescent catch-up sleep, white-matter maturation and internalizing problems ' , Developmental Cognitive Neuroscience , vol. 59 , 101193 . https://doi.org/10.1016/j.dcn.2022.101193; http://hdl.handle.net/10138/572310; 31794741-6c3e-4f44-8a95-16e89ef8c873; 000919370000001
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