Contributors: Hôpital Jean Verdier AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Service de Pédiatrie, Hopital Robert Debré (APHP); Université Paris Diderot - Paris 7 (UPD7); CHU Trousseau APHP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Service de Pédiatrie-Urgences Hopital Louis Mourier - APHP, Colombes; Hôpital Louis Mourier - AP-HP Colombes; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Centre Hospitalier Annecy-Genevois Saint-Julien-en-Genevois; Centre Hospitalier de Versailles André Mignot (CHV); CHU Rouen; Normandie Université (NU); Protection maternelle et infantile Seine-Saint-Denis, Bobigny; Santé de la femme enceinte et de l'enfant Paris (PMI); Ville de Paris; Centre de Ressource Biologique CHI Créteil (Centre de Recherche Clinique); Centre Hospitalier Intercommunal de Créteil (CHIC); AP-HP - Hôpital Antoine Béclère Clamart; Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV); Service de Microbiologie Clinique Hôpital Avicenne - APHP; Hôpital Avicenne AP-HP; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Mécanismes cellulaires et moléculaires des désordres hématologiques et implications thérapeutiques = Molecular mechanisms of hematological disorders and therapeutic implications (ERL 8254); Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)); École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité); COVIDOCRECHE collaborators: Lorelei Charbonnier, Anais Chosidow, Véronique Hentgen, Oscar Lescano, Nathalie Mestre, Gaelle Pinto Cardoso, Roselyne Masson, Bahia Rabehi, Anne-Sophie Romain, François Vié le Sage, Xavier Vuillaume
نبذة مختصرة : International audience ; Background The extent to which very young children contribute to the transmission of SARS-CoV-2 is unclear. We aimed to estimate the seroprevalence of antibodies against SARS-CoV-2 in daycare centres that remained open for key workers' children during a nationwide lockdown in France. Methods Children and staff who attended one of 22 daycare centres during a nationwide lockdown in France (between March 15 and May 9, 2020) were included in this cross-sectional, multicentre, seroprevalence study. Hospital staff not occupationally exposed to patients with COVID-19, or to children, were enrolled in a comparator group. The primary outcome was SARS-CoV-2 seroprevalence in children, daycare centre staff, and the comparator group. The presence of antibodies against SARS-CoV-2 in capillary whole blood was measured with a rapid chromatographic immunoassay. We computed raw prevalence as the percentage of individuals with a positive IgG or IgM test, and used Bayesian smoothing to account for imperfect sensitivity and specificity of the assay. This study is registered with ClinicalTrials.gov, NCT04413968. Findings Between June 4 and July 3, 2020, we enrolled 327 children (mean age 1•9 [SD 0•9] years; range 5 months to 4•4 years), 197 daycare centre staff (mean age 40 [12] years), and 164 adults in the comparator group (42 [12] years). Positive serological tests were observed for 14 children (raw seroprevalence 4•3%; 95% CI 2•6-7•1) and 14 daycare centre staff (7•7%; 4•2-11•6). After accounting for imperfect sensitivity and specificity of the assay, we estimated that 3•7% (95% credible interval [95% CrI] 1•3-6•8) of the children and 6•8% (3•2-11•5) of daycare centre staff had SARS-CoV-2 infection. The comparator group fared similarly to the daycare centre staff; nine participants had a positive serological test (raw seroprevalence 5•5%; 95% CI 2•9-10•1), leading to a seroprevalence of 5•0% (95% CrI 1•6-9•8) after accounting for assay characteristics. An exploratory analysis suggested that seropositive ...
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