Inkstų biopsijų indikacijų ir morfologinių radinių LSMU Nefrologijos klinikoje 2007- 2016m. analizė. ; Analysis of renal biopsy data in LUHS department of nephrology 2007– 2016

Purpose and objects: To analyse a results of renal biopsies from 2007 to 2016 in LUHS Department of Nephrology and evaluate indications,clinical manifestation of renal diseases and biopsy– proven diagnoses. Objects: 1. To investigate most common renal biopsies indications and their changing in 10 years. 2. To analyse renal biopsy– proven diseases incidences and possible dynamics in 10 years. 3. To compare a most common clinical manifestation of reanal diseases and morphological findings in renal biopsies. Methods: This study involved a data of renal biopsies of 1219 in LUHS Department of Nephrology patients from 2007 to 2016. Information about biopsy date, patient age and gender, biopsy indication and morphological finding was collected. Statistical analysis was performed using SPSS 23.0 package. Resullts: The average age of the subjects was 49.19 (± 15.09) years, 59.2% of them were men and 40.8% were women. A total 1219 kidney biopsies were performed, including 53.2% of transplant biopsies (n = 648, CI 95% = 0.5035–0.5595) and 46.8% of native biopsies (n = 571 CI 95% = 0.4405–0.4684). In our research we analyse only native (non–transplanted) kidney biopsies. The most common indications for kidney biopsies were chronic renal failure – 42.26% (n = 232), nephrotic syndrome – 27.32% (n = 150), acute renal failure – 9.84% (n = 54), rapidly progressive renal failure– 7.1%. (n = 39). Native kidney biopsies were classified as primary (57.27%, n = 327) and secondary (23.47%, n = 134) nephropathies. Among the primary nephropathies IgA nephropathy was found in 32.7%, crescentic glomerulonephritis in 18.3%, primary (10.4%) and secondary (10.1%) focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis and membranous nephropathy in 9.8% patients. Among secondary nephropathies, the most common diagnose were AA amyloidosis 17.2% (n = 23), thrombotic microangiopathy 15.7% (n = 21), diabetic nephropathy 11.9%. (n = 16). Conclusions: The most common indications for native kidney biopsy were chronic renal failure, nephrotic syndrome, acute renal failure and rapidly progressive renal failure. The most common morphological findings were IgA nephropathy, crescentic glomerulonephritis, primary and secondary focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis and membranous nephropathy. The most common biopsy–proven diagnoses for patients presenting with chronic renal failure were IgA nephropathy, primary and secondary focal segmental glomerulosclerosis. For patients presenting with nephrotic syndrome were membranous nephropathy IgA nephropathy and membranoproliferative glomerulonephritis.