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DURATION OF IMMUNE RESPONSE INDUCED BY THE VACCINE BASED ON RECOMBINANT Ag85, TB10 AND FliC PROTEINS ; ИЗУЧЕНИЕ ПРОДОЛЖИТЕЛЬНОСТИ ИММУННОГО ОТВЕТА, ИНДУЦИРОВАННОГО ВАКЦИНОЙ НА ОСНОВЕ РЕКОМБИНАНТНЫХ БЕЛКОВ Ag85, TB10 И FliC

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      SPb RAACI
    • الموضوع:
      2018
    • Collection:
      Medical Immunology (E-Journal) / Медицинская иммунология
    • نبذة مختصرة :
      Already about one hundred years BCG remains the only widely used tuberculosis (TB) vaccine. It is known that intensity of the BCG-induced Th1 immune response decreases over time and comes to naught within 10-15 years. It significantly distinguishes BCG from the vaccines providing a lifelong protection such as vaccines against poliomyelitis or measles, and can be bound to natural restriction of duration of a persistence of the BCG-induced CD4+ T-cells. Data on insufficient ability of BCG to stimulate life-long immunological memory is accumulating. Earlier in our lab on the model of rather resistant to TB C57BL/6 mice infection with the virulent laboratory strain of Mycobacterium tuberculosis (Mtb) H37Rv protective activity (comparable to that of BCG Russia) of 3 subunit vaccine variants was demonstrated as assessed by lung and spleen CFU counts and life span of animals after infection. The aim of this study was to study the characteristics and duration of the immune response induced by the most effective variant of these vaccines. Groups of C57BL/6 mice were vaccinated intramuscularly twice with two-week intervals with 10 μg protein conjugated to 200 μl of an aluminum hydroxide emulsion. Immune response (production of specific antibodies, vaccine proteinstimulated production of interferon gamma and proliferation in vitro) was monitored during 10 months after vaccination. We have shown that the test vaccine induces in mice the formation of long-term immunological memory to a bacterial antigen. Moreover, in the presence of glutoxim the immunological memory spectrum shifts to a "protective" type, i.e. the predominance of the cellular component of the immune response over the antibody response is stimulated. The next step will be the investigation of vaccine effectiveness for revaccination after primary BCG immunization. ; Вот уже около ста лет БЦЖ остается единственной широко используемой противотуберкулезной вакциной. Известно, что интенсивность индуцированного БЦЖ иммунного ответа по типу Th1 со временем снижается ...
    • File Description:
      application/pdf
    • Relation:
      https://www.mimmun.ru/mimmun/article/view/1483/1019; Еремеев В.В., Гергерт В.Я. Изучение способности препарата глутоксим влиять на антимикобактериальную активность фагоцитов чувствительных и устойчивых к туберкулёзу мышей // Туберкулез и болезни легких, 2013. № 7. С. 43-47. [Yeremeev V.V., Gergert V.Ya. Ivestigation of the ability of glutoxim to affect the antimycobacterial activity of phagocytes in tuberculosis susceptible and resistant mice. Tuberkulez i bolezni legkikh = Tuberculosis and Lung Desiases, 2013, no. 7, pp. 43-47. (In Russ.)]; Еремеев В.В., Духовлинов И.В., Орлов А.И., Маленко А.Ф., Федорова Е.А., Балазовский М.Б., Гергерт В.Я. Исследование протективных свойств вакцинного препарата на основе рекомбинантных белков Ag85, TB10 И FliC // Медицинская иммунология, 2017. Т. 19, № 2. С.197-202. [Yeremeev V.V., Dukhovlinov I.V., Orlov A.I., Malenko A.F., Fedorova E.A., Balazovsky M.B., Gergert V.Ya. Studies on protective effects of a vaccine, based on recombinant Ag85, TB10 and FliC proteins. Meditsinskaya immunologiya = Medical Immunology (Russia), 2017, Vol. 19, no. 2, pp. 197-202. (In Russ.)] doi:10.15789/1563-0625-2017-2-197-202.; A Randomized, Placebo Controlled, Partially Blinded Phase II Study to Evaluate Safety, Immunogenicity, and Prevention of Infection With Mycobacterium tuberculosis of AERAS-404 and BCG Revaccination in Healthy Adolescents (040-404). Available from: http://clinicaltrials.gov/show/NCT02075203.; Connor L.M., Harvie M.C., Rich F.J., Quinn K.M., Brinkmann V., Le Gros G., Kirman J.R. A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination. Eur. J. Immunol., 2010, Vol. 40, no. 9, pp. 2482-2492.; Coppola M., Arroyo L., van Meijgaarden K.E., Franken K.L., Geluk A., Barrera L.F., Ottenhoff T.H.M. Differences in IgG responses against infection phase related Mycobacterium tuberculosis (Mtb) specific antigens in individuals exposed or not to Mtb correlate with control of TB infection and progression. Tuberculosis, 2017, Vol. 106. pp. 25-32.; Fournillier A., Frelin L., Jacquier E., Ahlén G., Brass A., Gerossier E., Holmström F., Broderick K.E., Sardesai N.Y., Bonnefoy J.Y., Inchauspé G., Sällberg M. Heterologous prime/boost vaccination strategy enhances the immunogenicity of therapeutic vaccines for hepatitis C virus. J. Infect. Dis., 2013, Vol. 208, no. 6, pp. 1008-1019.; Kaufmann S.H., Weiner J., von Reyn C.F. Novel approaches to tuberculosis vaccine development. Int. J. Infect. Dis., 2017, Vol. 56, pp. 263-267.; Leroux-Roels I., Forgus S., De Boever F., Clement F., Demoitié M.A., Mettens P., Moris P., Ledent E., LerouxRoels G., Ofori-Anyinam O.l. Improved CD4+ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: A randomized trial. Vaccine, 2013, Vol. 31, no. 17, pp. 2196-2206.; Lindenstrom T., Agger E.M., Korsholm K.S., Darrah P.A., Aagaard C., Seder R.A., Rosenkrands I., Andersen P. Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells. J. Immunol., 2009, Vol. 182, no. 12, pp. 8047-8055.; Lindenstrom T., Knudsen N.P., Agger E.M., Andersen P. Control of chronic Mycobacterium tuberculosis infection by CD4 KLRG1- IL-2-secreting central memory cells. J. Immunol., 2013, Vol. 190, no. 12, pp. 6311-6319.; Lu S. Heterologous prime-boost vaccination. Curr. Opin. Immunol., 2009, Vol. 21, no. 3, pp. 346-351.; Orme I.M. The Achilles heel of BCG. Tuberculosis (Edinb.), 2010, Vol. 90, no. 6, pp. 329-332.; Reither K., Katsoulis L., Beattie T., Gardiner N., Lenz N., Said K., Mfinanga E., Pohl C., Fielding K.L., Jeffery H., Kagina B.M., Hughes E.J., Scriba T.J., Hanekom W.A., Hoff S.T., Bang P., Kromann I., Daubenberger C., Andersen P., Churchyard G.J. Safety and immunogenicity of H1/IC31(R), an adjuvanted TB subunit vaccine, in HIVinfected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. PLoS ONE, 2014, Vol. 9, no. 12, e114602. doi:10.1371/journal.pone.0114602.; Soares A.P., Kwong Chung C.K., Choice T., Hughes E.J., Jacobs G., van Rensburg E.J., Khomba G., de Kock M., Lerumo L., Makhethe L., Maneli M.H., Pienaar B., Smit E., Tena-Coki N.G., van Wyk L., Boom W.H., Kaplan G., Scriba T.J., Hanekom W.A. Longitudinal changes in CD4(+) T-cell memory responses induced by BCG vaccination of newborns. J. Infect. Dis., 2013, Vol. 207, no. 7, pp. 1084-1094.; Tyagi A.K., Nangpal P., Satchidanandam V. Development of vaccines against tuberculosis. Tuberculosis (Edinb), 2011, Vol. 91, no. 5, pp. 469-478.; Wells S.M., Kantor A.B., Stall A.M. CD43(S7) expression identifies peripheral B-cell subsets. J. Immunol., 1994, Vol. 153, no. 12, pp. 5503-5515.; https://www.mimmun.ru/mimmun/article/view/1483
    • الرقم المعرف:
      10.15789/1563-0625-2018-2-271-276
    • الدخول الالكتروني :
      https://www.mimmun.ru/mimmun/article/view/1483
      https://doi.org/10.15789/1563-0625-2018-2-271-276
    • Rights:
      Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). ; Авторы, публикующие в данном журнале, соглашаются со следующим:Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License, которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале.Авторы сохраняют право заключать отдельные контрактные договорённости, касающиеся не-эксклюзивного распространения версии работы в опубликованном здесь виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию в этом журнале.Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу (См. The Effect of Open Access).
    • الرقم المعرف:
      edsbas.3792CF33