Contributors: Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX); Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie; Centre régional de Pathologies Professionnelles et Environnementales des Hauts-de-France, Site d'Amiens, CHU Amiens Picardie (CRPPE HDF); CHU Amiens-Picardie; Autonomie, Gérontologie, E-santé, Imagerie & Société Grenoble (AGEIS); Université Grenoble Alpes (UGA); Environnement et Prévention en Santé des Populations (TIMC-EPSP ); Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ); VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ); Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ); CHU Grenoble; Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP); Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 (EDYSAN); Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)
نبذة مختصرة : Systematic screening for congenital hypothyroidism by heel-stick sampling has revealed unexpected heterogeneity in the geographic distribution of newborn thyroid-stimulating hormone concentrations in Picardy, France. We explored a possible relationship with environmental pollutants. Methods: Zip code geolocation data from mothers of newborns without congenital hypothyroidism born in were linked to ecological data for a set of airborne (particulate matter with a diameter of 2.5 μm or less [PM 2.5 ] or 10 μm or less [PM 10 ]) and tap-water (nitrate and perchlorate ions and atrazine) pollutants. Statistical associations between mean exposure levels during the third trimester of pregnancy and Thyroid-stimulating hormone (TSH) concentrations in 6249 newborns (51 % male) were investigated using linear regression models. Results: Median neonatal TSH concentration (interquartile range, IQR) was 1.7 (1-2.8) mIU/L. An increase of one IQR in prenatal exposure to perchlorate ions (3.6 μg/L), nitrate ions (19.2 mg/L), PM 2.5 (3.7 μg/m 3) and PM (3.4 μg/m 3), were associated with increases in TSH concentrations of 2.30 % (95 % CI: 0.95-3.66), 5.84 % (95 % CI: 2.81-8.87), 13.44 % (95 % CI: 9.65-17.28) and 6.26 % (95 % CI: 3.01-9.56), respectively. Conclusions: Prenatal exposure to perchlorate and nitrate ions in tap water and to airborne PM over the third trimester of pregnancy was significantly associated with increased neonatal TSH concentrations.
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