Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Taylor and Francis Ltd.
    • الموضوع:
      2021
    • Collection:
      NAOSITE: Nagasaki University Academic Output SITE / 長崎大学 学術研究成果リポジトリ
    • نبذة مختصرة :
      We previously found that a nanoparticle constructed with an antigen, benzalkonium chloride (BK) and γ-polyglutamic acid (γ-PGA) showed high Th1 and Th2-type immune induction after subcutaneous administration. For prophylaxis of respiratory infections, however, mucosal immunity should be induced. In this study, we investigated the effect of pulmonary administration of a nanoparticle comprising ovalbumin (OVA) as a model antigen, BK, and γ-PGA on induction of mucosal immunity in the lungs and serum. The complex was strongly taken up by RAW264.7 and DC2.4cells. After pulmonary administration, lung retention was longer for the OVA/BK/γ-PGA complex than for OVA alone. OVA-specific serum immunoglobulin (Ig)G was highly induced by the complex. High IgG and IgA levels were also induced in the bronchoalveolar lavage fluid, and in vivo toxicities were not observed. In conclusion, we effectively and safely induced mucosal immunity by pulmonary administration of an OVA/BK/γ-PGA complex. ; Drug Delivery, 28(1), pp. 1585-1593; 2021 ; journal article
    • File Description:
      application/pdf
    • ISSN:
      1071-7544
    • Relation:
      Drug Delivery; 28; 1585; 1593; https://nagasaki-u.repo.nii.ac.jp/record/26873/files/DD28_1585.pdf
    • الدخول الالكتروني :
      https://nagasaki-u.repo.nii.ac.jp/record/26873/files/DD28_1585.pdf
    • Rights:
      © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    • الرقم المعرف:
      edsbas.359A90F1