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Modulation of synaptic transmission through O-GlcNAcylation

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  • معلومة اضافية
    • Contributors:
      National Research Foundation
    • بيانات النشر:
      Springer Science and Business Media LLC
    • الموضوع:
      2024
    • نبذة مختصرة :
      O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase. In addition to roles in diabetes and cancer, recent pharmacological and genetic studies have revealed that O-GlcNAcylation is involved in neuronal function, specifically synaptic transmission. Global alteration of the O-GlcNAc level does not affect basal synaptic transmission while the effect on synaptic plasticity is unclear. Although synaptic proteins that are O-GlcNAcylated are gradually being discovered, the mechanism of how O-GlcNAcylated synaptic protein modulate synaptic transmission has only been reported on CREB, synapsin, and GluA2 subunit of AMPAR. Future research enabling the manipulation of O-GlcNAcylation in individual synaptic proteins should reveal hidden aspects of O-GlcNAcylated synaptic proteins as modulators of synaptic transmission.
    • الرقم المعرف:
      10.1186/s13041-023-01072-4
    • الرقم المعرف:
      10.1186/s13041-023-01072-4.pdf
    • الرقم المعرف:
      10.1186/s13041-023-01072-4/fulltext.html
    • الدخول الالكتروني :
      http://dx.doi.org/10.1186/s13041-023-01072-4
      https://link.springer.com/content/pdf/10.1186/s13041-023-01072-4.pdf
      https://link.springer.com/article/10.1186/s13041-023-01072-4/fulltext.html
    • Rights:
      https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0
    • الرقم المعرف:
      edsbas.342B8A74