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A saturated map of common genetic variants associated with human height

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  • معلومة اضافية
    • بيانات النشر:
      Umeå universitet, Enheten för biobanksforskning
      Umeå universitet, Institutionen för odontologi
      Umeå universitet, Avdelningen för hållbar hälsa
      Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, Australia
      Division of Endocrinology, Boston Children’s Hospital, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States
      William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
      Division of Endocrinology, Boston Children’s Hospital, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Harvard Medical School, MA, Boston, United States
      Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan; Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital and Department of Medicine, Harvard Medical School, MA, Boston, United States
      Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
      COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark
      23andMe, CA, Sunnyvale, United States
      Department of Veterans Affairs, Eastern Colorado Healthcare System, CO, Aurora, United States; Division of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, CO, Aurora, United States
      Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States
      Department of Internal Medicine, Division of Cardiology, University of Michigan, MI, Ann Arbor, United States
      Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, MA, Boston, United States; Department of Medicine, Harvard Medical School, MA, Boston, United States
      Department of Genetics, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, MA, Amherst, United States
      Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, MI, Ann Arbor, United States
      Department of Biostatistics and Data Science, Wake Forest School of Medicine, NC, Winston-Salem, United States
      Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom
      Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, United Kingdom
      Center for Health Data Science, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
      Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
      Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia
      Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
      Division of Biostatistics and Epidemiology, RTI International, NC, Durham, United States
      Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland
      Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore
      Department of Psychology, University of Minnesota, MN, Minneapolis, United States
      Steno Diabetes Center Copenhagen, Herlev, Denmark; Department of Biology, The Bioinformatics Center, University of Copenhagen, Copenhagen, Denmark
      Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
      Department of Family Medicine, University of California, San Diego, CA, La Jolla, United States
      Department of Human Genetics, David Geffen School of Medicine at UCLA, CA, Los Angeles, United States
      Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
      Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran
      Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark
      Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
      Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India
      Department of Epidemiology, University of Michigan School of Public Health, MI, Ann Arbor, United States
      Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
      Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, MD, Bethesda, United States
      Center for Applied Genomics, Children’s Hospital of Philadelphia, PA, Philadelphia, United States; Quantinuum Research, PA, Wayne, United States
      Department of Genetics, University of Pennsylvania, PA, Philadelphia, United States
      Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom
      Cardiovascular Health Research Unit, Department of Medicine, University of Washington, WA, Seattle, United States
      Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; NovoNordic Center for Protein Research, Copenhagen University, Copenhagen, Denmark
      Harvard Medical School, MA, Boston, United States; Department of Medicine, Brigham and Women’s Hospital, MA, Boston, United States
      Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
      Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
      Centre for Public Health, Queen’s University of Belfast, Belfast, United Kingdom
      Institute for Maternal and Child Health – IRCCS, Burlo Garofolo, Trieste, Italy
      Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore
      Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
      Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Graduate Institute of Medical Genomics and Proteomics, Medical College, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
      Department of Pathology and Laboratory Medicine, University of Pennsylvania, PA, Philadelphia, United States; Center for Spatial and Functional Genomics, Division of Human Genetics, Children’s Hospital of Philadelphia, PA, Philadelphia, United States
      Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, MA, Cambridge, United States
      Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
      Department of Kinesiology, Faculty of Medicine, Université Laval, QC, Québec City, Canada
      23andMe, CA, Sunnyvale, United States; Diamantina Institute, The University of Queensland, QLD, Brisbane, Australia
      Division of Preventive Medicine, Brigham and Women’s Hospital, MA, Boston, United States
      Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, MO, St Louis, United States
      Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Kiel, Germany
      Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
      Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Section of Statistical Multi-omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, United Kingdom
      Department of Biostatistics, Boston University School of Public Health, MA, Boston, United States
      Center for Data and Computational Sciences, VA Boston Healthcare System, MA, Boston, United States
      Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
      Department of Nutrition and Dietetics, School of Health and Education, Harokopio University of Athens, Athens, Greece
      Center for Precision Medicine, Wake Forest School of Medicine, Medical Center Boulevard, NC, Winston-Salem, United States
      Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore; Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore
      Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
      Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom
      Survey Research Center, Institute for Social Research, University of Michigan, MI, Ann Arbor, United States
      Computational Genomics Department, National Institute of Genomic Medicine, Mexico City, Mexico
      Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria
      Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy
      Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany
      Eurac Research, Institute for Biomedicine, Affiliated Institute of the University of Lübeck, Bolzano, Italy
      Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, Netherlands
      Jackson Heart Study, Department of Medicine, University of Mississippi, MS, Jackson, United States
      Nanjing University of Chinese Medicine, Nanjing, China; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany
      Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
      Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
      Genetic Epidemiology, QIMR Berghofer Medical Research Institute, QLD, Brisbane, Australia
      Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany
      Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; BiRC—Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
      Department of Medical Sciences, Uppsala University, Uppsala, Sweden
      Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
      Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark; NovoNordic Center for Protein Research, Copenhagen University, Copenhagen, Denmark; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Rigshospitalet, Denmark
      Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
      MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Bristol Dental School, University of Bristol, Bristol, United Kingdom
      Department of Neurology, Boston University School of Medicine, MA, Boston, United States; Framingham Heart Study, MA, Framingham, United States
      Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait
      Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
      Veterans Affairs Boston Healthcare System, MA, Boston, United States
      Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
      School of Medicine and Public Health, University of Newcastle, NSW, Callaghan, Australia
      Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Medical Faculty, Leipzig, Germany; LIFE Research Center for Civilization Diseases, University of Leipzig, Medical Faculty, Leipzig, Germany
      Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
      Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
      School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China; Institute for Global Health and Development, Peking University, Beijing, China
      Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México Ciudad Universitaria, Mexico City, Mexico; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico
      Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan
      Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
      Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea
      Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Tokushima, Japan
      Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
      Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany
      Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; Department of Child and Adolescent Psychiatry and Pediatric Psychology, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, Netherlands
      Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland; Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
      Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
      Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan
      Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
      Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
      Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan
      Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
      Department of Psychiatry, University of Pennsylvania, PA, Philadelphia, United States
      Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom; Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
      Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Clinical Research Design and Evaluation (SAIHST), Sungkyunkwan University, Seoul, South Korea
      Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany
      Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
      Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden
      Department of Computer Science, University of Toronto, ON, Toronto, Canada; Department of Anthropology, University of Toronto at Mississauga, ON, Mississauga, Canada
      Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, QLD, Kelvin Grove, Australia
      Oneomics, Soonchunhyang Mirai Medical Center, Bucheon-si, South Korea
      Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, MD, Bethesda, United States; Center for Alzheimer’s and Related Dementias, National Institutes of Health, MD, Bethesda, United States; Data Tecnica International, MD, Glen Echo, United States
      Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States; Cancer Genomics Research Laboratory, Leidos Biomedical Research, MD, Rockville, United States
      Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States; Department of Mathematics and Statistics, St Cloud State University, MN, St Cloud, United States
      Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States
      Department of Medicine, University of Massachusetts Chan Medical School, MA, Worcester, United States
      Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan
      Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
      Montreal Heart Institute, QC, Montreal, Canada
      Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
      MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
      Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway; Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden
      Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland
      Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan
      National and Kapodistrian University of Athens, Dromokaiteio Psychiatric Hospital, Athens, Greece
      Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom; NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, United Kingdom
      Center for Public Health Genomics, University of Virginia School of Medicine, VA, Charlottesville, United States
      MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
      Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany
      Department of Medicine, Harvard Medical School, MA, Boston, United States; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Diabetes Unit, Massachusetts General Hospital, MA, Boston, United States; Center for Genomic Medicine, Massachusetts General Hospital, MA, Boston, United States
      Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC and Vrije Universiteit, Amsterdam, Netherlands
      Biomedical and Translational Informatics Institute, Geisinger, PA, Danville, United States; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
      Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
      Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
      MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
      Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research) partner site Hamburg/Lübeck/Kiel and University Heart Center Lübeck, Lübeck, Germany
      Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
      Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
      Korea Institute of Science and Technology, Gangneung Institute of Natural Products, Gangneung, South Korea
      Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark
      Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
      Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom
      Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
      Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy
      Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom
      Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
      Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Aabenraa, Denmark
      Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
      Medical School, University of Split, Split, Croatia; Algebra University College, Zagreb, Croatia
      Harvard Medical School, MA, Boston, United States; Department of Medicine, Brigham and Women’s Hospital, MA, Boston, United States; Center for Data and Computational Sciences, VA Boston Healthcare System, MA, Boston, United States
      Department of Genetics, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
      William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Aragon Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain
      Center for Non-Communicable Diseases, Karachi, Pakistan
      Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
      Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
      Hunter Medical Research Institute, NSW, New Lambton Heights, Australia; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, NSW, New Lambton Heights, Australia
      Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy; IRCCS Neuromed, Pozzilli, Italy
      Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, MD, Baltimore, United States; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, MD, Baltimore, United States
      Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
      Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Center for Genomic Medicine, Massachusetts General Hospital, MA, Boston, United States
      Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, MD, Baltimore, United States
      Department of Biomedical Science, Hallym University, Chuncheon, South Korea
      Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy
      Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands; Epidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, Netherlands; Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands
      Department of Epidemiology, University of Michigan School of Public Health, MI, Ann Arbor, United States; Icelandic Heart Association, Kópavogur, Iceland
      Department of Epidemiology, University of Michigan School of Public Health, MI, Ann Arbor, United States; Survey Research Center, Institute for Social Research, University of Michigan, MI, Ann Arbor, United States
      Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Wellcome Sanger Institute, Hinxton, United Kingdom
      deCODE Genetics/Amgen, Reykjavik, Iceland
      Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway
      Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, IL, Maywood, United States
      VA Palo Alto Health Care System, CA, Palo Alto, United States; Department of Medicine, Stanford University School of Medicine, CA, Stanford, United States
      Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
      Cardiology Division, Department of Pediatrics, University of California, San Francisco, CA, Oakland, United States
      Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
      Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
      Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands
      Central Diagnostics Laboratory, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
      Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands; Laboratory Genetic Metabolic Diseases, Department of Clinical Chemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Core Facility Metabolomics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
      Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
      Department of Pathology and Laboratory Medicine, University of Pennsylvania, PA, Philadelphia, United States
      Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
      Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
      Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
      Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; Department of Dermatology, Medical University of Vienna, Vienna, Austria
      Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway; Department of Neurology, Oslo University Hospital, Oslo, Norway
      MRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, United Kingdom
      Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany; Department of Medicine IV – Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
      Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX, Houston, United States
      Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan
      Rush Alzheimer’s Disease Center, Rush University Medical Center, IL, Chicago, United States; Department of Neurological Sciences, Rush University Medical Center, IL, Chicago, United States
      Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar; Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt
      Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany
      Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
      Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom
      Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Department of Computational Medicine and Bioinformatics, University of Michigan, MI, Ann Arbor, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, MA, Boston, United States; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, Cambridge, United States
      Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Carolina Population Center, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
      Department of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile
      Unidad de Investigacion de Enfermedades Metabolicas and Direction of Nutrition, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico; Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Mexico
      Department of Epidemiology and Dean’s Office, College of Public Health, University of Kentucky, KY, Lexington, United States
      Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom; Health Data Research UK and Institute of Health Informatics, University College London, London, United Kingdom
      KG Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
      Department of Nephrology, University Hospital Regensburg, Regensburg, Germany
      Geriatric Unit, Azienda Toscana Centro, Florence, Italy
      Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University (JNU), New Delhi, India
      Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy
      COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
      Human Genetics Center and Department of Epidemiology, University of Texas Health Science Center at Houston, TX, Houston, United States
      Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany; KfH Kidney Center Traunstein, Traunstein, Germany
      Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
      USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines; Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines
      Human Genomics Laboratory, Pennington Biomedical Research Center, LA, Baton Rouge, United States
      Center for Precision Medicine, Wake Forest School of Medicine, Medical Center Boulevard, NC, Winston-Salem, United States; Department of Biochemistry, Wake Forest School of Medicine, Medical Center Boulevard, NC, Winston-Salem, United States
      Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
      KG Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
      Harvard Medical School, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women’s Hospital, MA, Boston, United States
      Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, United Kingdom; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; Imperial College Healthcare NHS Trust, Imperial College London, London, United Kingdom
      Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India; Adjunct Faculty, JSS University Academy of Higher Education and Research (JSSAHER), JSS (Deemed to be) University, Mysuru, India
      Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore
      Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway
      Department of Neurology, Division of Vascular Neurology, University of Maryland School of Medicine, MD, Baltimore, United States; Baltimore Veterans Affairs Medical Center, Department of Neurology, MD, Baltimore, United States
      Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
      Department of Biostatistics, Boston University School of Public Health, MA, Boston, United States; Framingham Heart Study, MA, Framingham, United States
      Intermountain Heart Institute, Intermountain Medical Center, UT, Murray, United States
      Department of Genetics, University of Pennsylvania, PA, Philadelphia, United States; Department of Surgery, University of Pennsylvania, PA, Philadelphia, United States; Corporal Michael J. Crescenz VA Medical Center, PA, Philadelphia, United States
      Department of Vascular Surgery, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands
      Department of Human Nutrition, Wageningen University, Wageningen, Netherlands
      Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, NY, New York, United States
      Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom; Department of Oncology, University of Cambridge, Cambridge, United Kingdom
      Department of General Practice, Amsterdam Public Health Institute, Amsterdam UMC, location VUmc, Amsterdam, Netherlands
      Department of Medicine, Brigham and Women’s Hospital, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
      Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Cardiac Arrhythmia Service, Massachusetts General Hospital, MA, Boston, United States; Cardiovascular Research Center, Massachusetts General Hospital, MA, Boston, United States
      Department of Clinical Sciences in Malmö, Division of Geriatric Medicine, Lund University, Malmö, Sweden
      Molecular Cardiology Division, Victor Chang Cardiac Research Institute, NSW, Darlinghurst, Australia; Cardiology Department, St Vincent’s Hospital, NSW, Darlinghurst, Australia; Faculty of Medicine, UNSW Sydney, NSW, Kensington, Australia
      Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, MD, Baltimore, United States
      Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom
      Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX, Houston, United States; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, TX, Houston, United States
      Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
      Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, NC, Winston-Salem, United States
      Institute for Maternal and Child Health – IRCCS, Burlo Garofolo, Trieste, Italy; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy
      Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany
      Faculty of Veterinary and Agricultural Science, University of Melbourne, VIC, Parkville, Australia; Agriculture Victoria Research, Department of Jobs, Precincts and Regions, VIC, Bundoora, Australia
      Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Injury Prevention Research Center, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Division of Physical Therapy, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
      Centro de Investigacion en Salud Poblacional Instituto Nacional de Salud Publica and Centro de Estudios en Diabetes, Cuernavaca, Mexico
      Center for Applied Genomics, Children’s Hospital of Philadelphia, PA, Philadelphia, United States; Division of Human Genetics, Children’s Hospital of Philadelphia, PA, Philadelphia, United States; Departments of Pediatrics and Genetics, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States; Division of Endocrinology and Diabetes, Children’s Hospital of Philadelphia, PA, Philadelphia, United States
      Icelandic Heart Association, Kópavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland
      Department of Preventive Medicine, Keck School of Medicine of USC, CA, Los Angeles, United States
      Center for Applied Genomics, Children’s Hospital of Philadelphia, PA, Philadelphia, United States; Division of Human Genetics, Children’s Hospital of Philadelphia, PA, Philadelphia, United States; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States; Division of Pulmonary Medicine, Children’s Hospital of Philadelphia, PA, Philadelphia, United States
      Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom
      Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, WA, Seattle, United States
      Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Khoo Teck Puat - National University Children’s Medical Institute, National University Health System, Singapore, Singapore
      Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria
      Menzies Research Institute Tasmania, University of Tasmania, TAS, Hobart, Australia; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, VIC, Melbourne, Australia; Lions Eye Institute, Centre for Ophthalmology and Vision Science, University of Western Australia, WA, Perth, Australia
      Harvard Medical School, MA, Boston, United States; Cardiovascular Research Center, Massachusetts General Hospital, MA, Boston, United States; Cardiology Division, Massachusetts General Hospital, MA, Boston, United States
      Department of Genetics, Shanghai-MOST Key Laboratory of Heath and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute, Shanghai, China
      Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar; Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
      KG Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway
      Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, SA, Adelaide, Australia; South Australian Health and Medical Research Institute, SA, Adelaide, Australia
      Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan
      Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
      Division of Endocrinology, Diabetes and Metabolism, School of Medicine, Ohio State University, OH, Columbus, United States
      Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, United Kingdom
      Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China
      Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
      Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
      Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, Netherlands; Netherlands Heart Institute, Utrecht, Netherlands
      Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
      Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
      Department of Ophthalmology, The Catholic University of Korea Incheon St. Mary’s Hospital, Incheon, South Korea
      Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
      Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
      Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, Netherlands; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Urology, Nijmegen, Netherlands
      Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, South Korea; Saevit Eye Hospital, Goyang, South Korea
      Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, South Korea
      Department of Cardiology, University Heart and Vascular Center UKE Hamburg, Hamburg, Germany; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; German Center for Cardiovascular Research, partner site Hamburg/Kiel/Lübeck, Hamburg, Germany; Atrial Fibrillation NETwork, Münster, Germany
      Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, United Kingdom
      Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
      Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; University of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
      Department of Preventive Cardiology, Lipoprotein Apheresis Unit and Lipid Disorders Clinic, Metropolitan Hospital, Athens, Greece
      Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, United Kingdom; Imperial College Healthcare NHS Trust, Imperial College London, London, United Kingdom; MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom
      Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
      Medical Department III – Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany
      Institute for Social and Economic Research, University of Essex, Colchester, United Kingdom
      Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
      Department of Medicine, University of Colorado at Denver, CO, Aurora, United States
      MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
      Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States
      Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea
      USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines
      Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, China; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China
      Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany
      Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China; Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, China
      Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
      Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa Hospitals and Clinics, IA, Iowa City, United States
      Alliance for Human Development, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, ON, Toronto, Canada
      Menzies Research Institute Tasmania, University of Tasmania, TAS, Hobart, Australia; Lions Eye Institute, Centre for Ophthalmology and Vision Science, University of Western Australia, WA, Perth, Australia
      Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
      Division of Cardiology, University of California, San Francisco, CA, San Francisco, United States
      Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland; University of Lausanne, Lausanne, Switzerland
      Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; SYNLAB Academy, SYNLAB Holding Deutschland, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
      Department of Medicine, Division of Cardiology, Duke University School of Medicine, NC, Durham, United States; Duke Molecular Physiology Institute, Duke University School of Medicine, NC, Durham, United States
      Psychiatric Genetics, QIMR Berghofer Medical Research Institute, QLD, Brisbane, Australia
      Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
      Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, MD, Baltimore, United States; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, MD, Baltimore, United States; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, MD, Baltimore, United States
      Centre for Vision Research and Department of Ophthalmology, Westmead Millennium Institute of Medical Research, University of Sydney, NSW, Sydney, Australia
      Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands
      Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
      Electrophysiology Section, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
      Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Department of Medicine, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
      Center for Genomic Medicine, Massachusetts General Hospital, MA, Boston, United States; Cardiovascular Research Center, Massachusetts General Hospital, MA, Boston, United States
      Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway; Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway
      Institute of Human Genetics, School of Medicine and University Hospital Bonn, Bonn, Germany
      Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden
      Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, CDMX, Mexico City, Mexico
      Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland
      Department of Human Genetics, David Geffen School of Medicine at UCLA, CA, Los Angeles, United States; Institute for Precision Health, David Geffen School of Medicine at UCLA, CA, Los Angeles, United States
      Pat MacPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom
      Department of Anthropology, University of Toronto at Mississauga, ON, Mississauga, Canada
      Department of Kinesiology, Faculty of Medicine, Université Laval, QC, Québec City, Canada; Centre Nutrition, Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods, Université Laval, QC, Québec City, Canada
      Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; IBE, LMU Munich, Neuherberg, Germany
      Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
      Population, Policy and Practice, UCL Great Ormond Street Hospital Institute of Child Health, London, United Kingdom
      Department of Genetics, University of Pennsylvania, PA, Philadelphia, United States; Department of Medicine, University of Pennsylvania, PA, Philadelphia, United States
      Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
      Hero DMC Heart Institute, Dyanand Medical College, Ludhiana, India
      Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital Attikon, Athens, Greece
      Division of Biostatistics, Washington University School of Medicine, MO, St Louis, United States
      Genetics, Merck Sharp & Dohme, NJ, Kenilworth, United States
      Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
      Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, South Korea
      Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Department of Public Health, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland
      Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, TN, Nashville, United States
      Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
      Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom
      Department of Epidemiology and Data Science, Amsterdam Public Health Institute, Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, location VUmc, Amsterdam, Netherlands
      Center for Non-Communicable Diseases, Karachi, Pakistan; Department of Cardiology and Department of Medicine, Columbia University, NY, New York, United States
      Department of Pediatrics, Section of Genetics, College of Medicine, University of Oklahoma Health Sciences Center, OK, Oklahoma City, United States; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, OK, Oklahoma City, United States; Department of Physiology, University of Oklahoma Health Sciences Center, OK, Oklahoma City, United States; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, OK, Oklahoma City, United States
      Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
      Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria
      Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria
      Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
      Deutsches Herzzentrum München, Cardiology, Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK) – Munich Heart Alliance, and Technische Universität München, München, Germany
      School of Biomedical Science and Pharmacy, University of Newcastle, NSW, New Lambton Heights, Australia
      National Heart and Lung Institute, Imperial College London, London, United Kingdom
      Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
      Central University of Punjab, Bathinda, India
      Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, MD, Bethesda, United States
      German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany
      Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden
      Population Health Research Institute, St George’s, University of London, London, United Kingdom
      Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands; Epidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, Netherlands; Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands; Molecular Epidemiology Section, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands
      Department of Genetics, Stanford University School of Medicine, CA, Stanford, United States
      Montreal Heart Institute, QC, Montreal, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, QC, Montreal, Canada
      Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden; Helsinki University Central Hospital, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland
      Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
      Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
      Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore; Milken Institute School of Public Health, The George Washington University, DC, Washington, United States
      Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
      Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department Geriatric Medicine, Amsterdam Public Health, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands
      Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands
      DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
      Unidad de Investigación Médica en Epidemiología Clínica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
      Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
      Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
      Department of Population and Public Health Sciences, Keck School of Medicine of USC, CA, Los Angeles, United States; Department of Physiology and Neuroscience, Keck School of Medicine of USC, CA, Los Angeles, United States; USC Diabetes and Obesity Research Institute, Keck School of Medicine of USC, CA, Los Angeles, United States
      Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Lundbeck Foundation Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark
      Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
      Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan
      Diabetes Unit, KEM Hospital and Research Centre, Pune, India
      Kurume University School of Medicine, Kurume, Japan
      Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
      Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Wellcome Sanger Institute, Hinxton, United Kingdom; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany
      Department of Genetics, University of Pennsylvania, PA, Philadelphia, United States; Center for Spatial and Functional Genomics, Division of Human Genetics, Children’s Hospital of Philadelphia, PA, Philadelphia, United States; Division of Endocrinology and Diabetes, Children’s Hospital of Philadelphia, PA, Philadelphia, United States; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
      Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
      Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
      Department of Epidemiology, Emory University Rollins School of Public Health, GA, Atlanta, United States; Atlanta VA Health Care System, GA, Decatur, United States
      Department of Medicine, Brigham and Women’s Hospital, MA, Boston, United States
      Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Genentech, CA, South San Francisco, United States
      Center for Precision Medicine, Wake Forest School of Medicine, Medical Center Boulevard, NC, Winston-Salem, United States; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
      Harvard Medical School, MA, Boston, United States; Department of Medicine, Brigham and Women’s Hospital, MA, Boston, United States; Department of Medicine, Veterans Affairs Boston Healthcare System, MA, Boston, United States
      deCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland
      Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore
      William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia
      Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Department of Population Health Sciences, Geisinger, PA, Danville, United States
      Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
      Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, NY, New York, United States; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United States; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, NY, New York, United States
      Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, Australia; School of Life Sciences, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China
      Department of Internal Medicine, Division of Cardiology, University of Michigan, MI, Ann Arbor, United States; Department of Computational Medicine and Bioinformatics, University of Michigan, MI, Ann Arbor, United States; Department of Human Genetics, University of Michigan, MI, Ann Arbor, United States
      McDonnell Genome Institute and Department of Medicine, Washington University School of Medicine, MO, St Louis, United States
      Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
      Division of Endocrinology, Boston Children’s Hospital, MA, Boston, United States; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Departments of Pediatrics and Genetics, Harvard Medical School, MA, Boston, United States
      Dipartimento di Scienze Mediche Chirurgiche e Sperimentali, Università degli Studi di Sassari, Sassari, Italy
      The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, CA, Torrance, United States
      The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; The National Centre for Register-based Research, University of Aarhus, Aarhus, Denmark
      The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, NY, New York, United States; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United States
      The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, NY, New York, United States; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
      The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, NY, New York, United States
      Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy
      Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom
      The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China
    • الموضوع:
      2022
    • Collection:
      Umeå University: Publications (DiVA)
    • نبذة مختصرة :
      Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10–20% (14–24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.
    • File Description:
      application/pdf
    • Relation:
      Nature, 0028-0836, 2022, 610:7933, s. 704-712; orcid:0000-0002-9227-8434; http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200546; PMID 36224396; ISI:000866362700001; Scopus 2-s2.0-85139748621
    • الرقم المعرف:
      10.1038/s41586-022-05275-y
    • Rights:
      info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.3371F46F